Linked Life Data

15200426

Source:http://linkedlifedata.com/resource/pubmed/id/15200426

Statements in which the resource exists.
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pubmed-article:15200426pubmed:abstractTextCisplatin and its analogs oxaliplatin and carboplatin are widely used antitumor drugs. Nephrotoxicity is a common and relevant adverse effect that occurs especially in cisplatin therapy. Cellular and molecular mechanisms of cisplatin-induced nephrotoxicity are not completely understood. The nephrotoxicity of platinum complexes was evaluated by a new in vitro system that utilizes the high Trans Epithelial Electrical Resistance (TEER) of the C7 clone of the MDCK (Madin-Darby canine kidney) cells. By means of this assay system we addressed the question whether the side of application of renal epithelia influences platinum complex toxicity.lld:pubmed
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pubmed-article:15200426pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15200426pubmed:articleTitleNephrotoxicity of platinum complexes is related to basolateral organic cation transport.lld:pubmed
pubmed-article:15200426pubmed:affiliationInstitut für Physiologie II, Westfälische Wilhelms-Universität Münster, Münster, Germany. thomas.ludwig@uni-muenster.delld:pubmed
pubmed-article:15200426pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15200426pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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