| pubmed-article:15191913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0030306 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:15191913 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15191913 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15191913 | pubmed:dateCreated | 2004-8-19 | lld:pubmed |
| pubmed-article:15191913 | pubmed:abstractText | Uncontrolled elastase activity is involved in the development of several types of lung disease. Previous reports demonstrated that growth factors are liberated from pulmonary matrix storage sites by elastase; however, release of these entities in vivo is not well defined. In the present study, we investigated the release of fibroblast growth factor-2 (FGF-2) and transforming growth factor-beta (TGF-beta), after intratracheal instillation of porcine pancreatic elastase into mice. We found that elastase promoted a time-dependent release of FGF-2 and TGF-beta1 from the lung into bronchoalveolar lavage (BAL) fluid. A large fraction of the TGF-beta1 in BAL fluid was in the active form (approximately 60%), suggesting that elastase might participate in the activation of TGF-beta1 from its latent form. Analysis of the levels of FGF-2 and TGF-beta1 in mouse blood indicated that the growth factors in BAL fluid were not entirely derived from blood. Moreover, elastase treatment of pulmonary fibroblasts cultures caused the release of TGF-beta1, suggesting that the TGF-beta1 in BAL fluid could have come from lung cells/matrix. Additional in vitro studies also indicated that TGF-beta1 plays a role in upregulating elastin mRNA levels. These data suggest that elastase releases growth factors from lung that participate in elastolytic injury responses. | lld:pubmed |
| pubmed-article:15191913 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15191913 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15191913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15191913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15191913 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15191913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15191913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15191913 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15191913 | pubmed:issn | 1044-1549 | lld:pubmed |
| pubmed-article:15191913 | pubmed:author | pubmed-author:LuceyEdgar... | lld:pubmed |
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| pubmed-article:15191913 | pubmed:author | pubmed-author:FosterJudith... | lld:pubmed |
| pubmed-article:15191913 | pubmed:author | pubmed-author:RichCeleste... | lld:pubmed |
| pubmed-article:15191913 | pubmed:author | pubmed-author:Buczek-Thomas... | lld:pubmed |
| pubmed-article:15191913 | pubmed:author | pubmed-author:ChuChia LCL | lld:pubmed |
| pubmed-article:15191913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15191913 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:15191913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15191913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15191913 | pubmed:pagination | 344-50 | lld:pubmed |
| pubmed-article:15191913 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15191913 | pubmed:meshHeading | pubmed-meshheading:15191913... | lld:pubmed |
| pubmed-article:15191913 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15191913 | pubmed:articleTitle | Elastase mediates the release of growth factors from lung in vivo. | lld:pubmed |
| pubmed-article:15191913 | pubmed:affiliation | Department of Biochemistry and the Pulmonary Center at Boston University School of Medicine, Boston, MA 02118, USA. | lld:pubmed |
| pubmed-article:15191913 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15191913 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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