Linked Life Data

15168600

Source:http://linkedlifedata.com/resource/pubmed/id/15168600

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pubmed-article:15168600pubmed:abstractTextSevere fungal infections remain a significant cause of morbidity and mortality in neutropenic patients undergoing dose-intensive chemotherapy for malignant diseases. Chronic disseminated candidiasis (CDC) is a life-threatening complication in neutropenic patients because of the lack of responsive hematopoietic precursor cells. Resolution of Candida organ lesions after hematopoietic reconstitution may take months. Here, we report the case of a 19-year-old neutropenic woman with relapsed acute myelogenous leukemia and candidiasis of liver, spleen, and kidneys. Antifungal treatment was initiated using fluconazole and caspofungin but was changed to itraconazole and caspofungin. Despite elevated C-reactive protein (CRP) levels and detectable Candida organ lesions, antileukemic therapy was restarted with interleukin 2 at the same time as antimicrobial treatment. Eight weeks after the start of interleukin therapy, CRP levels and organ lesions were decreased significantly irrespective of continuing neutropenia. This case report describes the successful treatment of CDC during neutropenia using combination antifungal therapy and suggests controlled studies to establish optimal therapeutic strategies.lld:pubmed
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pubmed-article:15168600pubmed:pagination289-92lld:pubmed
pubmed-article:15168600pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:15168600pubmed:year2004lld:pubmed
pubmed-article:15168600pubmed:articleTitleSuccessful treatment of chronic disseminated candidiasis with caspofungin and itraconazole in a patient with progressive acute leukemia and prolonged neutropenia.lld:pubmed
pubmed-article:15168600pubmed:affiliationKlinik I für Innere Medizin, Klinikum der Universität zu Köln, Joseph-Stelzmann-Str. 9, 50924 Köln, Germany. kai.huebel@uni-koeln.delld:pubmed
pubmed-article:15168600pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15168600pubmed:publicationTypeCase Reportslld:pubmed