| pubmed-article:15163734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1412933 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:15163734 | lifeskim:mentions | umls-concept:C0598995 | lld:lifeskim |
| pubmed-article:15163734 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15163734 | pubmed:dateCreated | 2004-5-27 | lld:pubmed |
| pubmed-article:15163734 | pubmed:abstractText | Complement plays a pivotal role in the regulation of innate and adaptive immunity. It has been shown that the binding of C1q, a natural ligand of gC1qR, on T cells inhibits their proliferation. Here, we demonstrate that direct binding of the hepatitis C virus (HCV) core to gC1qR on T cells leads to impaired Lck/Akt activation and T-cell function. The HCV core associates with the surface of T cells specifically via gC1qR, as this binding is inhibited by the addition of either anti-gC1qR antibody or soluble gC1qR. The binding affinity constant of core protein for gC1qR, as determined by BIAcore analysis, is 3.8 x 10(-7) M. The specificity of the HCV core-gC1qR interaction is confirmed by reduced core binding on Molt-4 T cells treated with gC1qR-silencing small interfering RNA and enhanced core binding on GPC-16 guinea pig cells transfected with human gC1qR. Interestingly, gC1qR is expressed at higher levels on CD8(+) than on CD4(+) T cells, resulting in more severe core-induced suppression of the CD8(+)-T-cell population. Importantly, T-cell receptor-mediated activation of the Src kinases Lck and ZAP-70 but not Fyn and the phosphorylation of Akt are impaired by the HCV core, suggesting that it inhibits the very early events of T-cell activation. | lld:pubmed |
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| pubmed-article:15163734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15163734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15163734 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15163734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15163734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15163734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15163734 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15163734 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15163734 | pubmed:author | pubmed-author:HahnYoung SYS | lld:pubmed |
| pubmed-article:15163734 | pubmed:author | pubmed-author:Eisen-Vanderv... | lld:pubmed |
| pubmed-article:15163734 | pubmed:author | pubmed-author:YaoZhi... | lld:pubmed |
| pubmed-article:15163734 | pubmed:author | pubmed-author:WaggonerSteph... | lld:pubmed |
| pubmed-article:15163734 | pubmed:author | pubmed-author:CaleEvan MEM | lld:pubmed |
| pubmed-article:15163734 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15163734 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:15163734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15163734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15163734 | pubmed:pagination | 6409-19 | lld:pubmed |
| pubmed-article:15163734 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15163734 | pubmed:meshHeading | pubmed-meshheading:15163734... | lld:pubmed |
| pubmed-article:15163734 | pubmed:meshHeading | pubmed-meshheading:15163734... | lld:pubmed |
