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pubmed-article:15151978pubmed:abstractTextMetaiodobenzylguanidine (MIBG) labelled with iodine-131 ((131)I) has become a well established therapeutic tool for inoperable metastastic tumours of paraganglioma. There are different pharmacological substances known to interfere with MIBG-uptake which may result in a false negative MIBG scan. We present the case of a 26-year-old male polytoxicomanic patient with metastatic paraganglioma, who underwent MIBG therapy. During earlier therapies, MIBG uptake in the metastatic lesions was very high. A post-therapeutic whole-body scan subsequent to recent (131)I-MIBG therapy failed to detect the vast majority of metastatic lesions-except for two. (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) showed metastases with a similar distribution to the initial MIBG scan. The possible reasons for the discrepancy in the findings of the MIBG scans and the (18)F-FDG-PET scan are discussed with special emphasis on drug intake prior to MIBG administration, increased MIBG turn-over and unknown drug mixture interference with MIBG uptake.lld:pubmed
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pubmed-article:15151978pubmed:volume77lld:pubmed
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pubmed-article:15151978pubmed:pagination525-7lld:pubmed
pubmed-article:15151978pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:15151978pubmed:year2004lld:pubmed
pubmed-article:15151978pubmed:articleTitleCase report: drug interference with MIBG uptake in a patient with metastatic paraganglioma.lld:pubmed
pubmed-article:15151978pubmed:affiliationDepartment of Nuclear Medicine, Hospital of the J.W. Goethe-University, Frankfurt/Main, Germany.lld:pubmed
pubmed-article:15151978pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15151978pubmed:publicationTypeCase Reportslld:pubmed