| pubmed-article:15146310 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15146310 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:15146310 | lifeskim:mentions | umls-concept:C1858460 | lld:lifeskim |
| pubmed-article:15146310 | lifeskim:mentions | umls-concept:C0039635 | lld:lifeskim |
| pubmed-article:15146310 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15146310 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:15146310 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15146310 | pubmed:dateCreated | 2004-5-17 | lld:pubmed |
| pubmed-article:15146310 | pubmed:abstractText | Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngeneically pregnant or virgin female mice were injected intraperitoneally with 10 micro g/kg TCDD. Pregnancy alone significantly decreased thymic cellularity and J11d expression as well as induced changes in T-cell subsets. TCDD treatment caused significant thymic atrophy in pregnant mice as early as 48 h after exposure, but this effect was apparent in virgin mice only after 72 h. TCDD treatment also caused more marked alterations in thymic T-cell subpopulations of pregnant mice when compared to the virgin mice, with a decrease in the percentage of double-positive T cells and an increase in the percentage of single-positive (sP CD4(+) or sP CD8(+)) and double-negative T cells. Moreover, the proliferative responses of thymocytes, but not splenocytes, to mitogens were significantly altered in TCDD-treated pregnant mice when compared to the TCDD-treated virgin mice. Furthermore, no significant changes in the expression of CD4, CD8, B220 and NK1.1 markers were found in splenocytes from TCDD-treated virgin and pregnant mice. Immunization of mice with a superantigen caused a similar immunotoxic response in TCDD-treated pregnant and virgin mice with a decreased lymph node cellularity and lower percentages and cell numbers of Vbeta3(+) and Vbeta11(+) T cells. Together, the results of the current study demonstrate for the first time that pregnancy augments the sensitivity to TCDD-induced immunotoxicity in the thymus, but not in secondary lymphoid organs. | lld:pubmed |
| pubmed-article:15146310 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15146310 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15146310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15146310 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15146310 | pubmed:month | May | lld:pubmed |
| pubmed-article:15146310 | pubmed:issn | 0340-5761 | lld:pubmed |
| pubmed-article:15146310 | pubmed:author | pubmed-author:NagarkattiPra... | lld:pubmed |
| pubmed-article:15146310 | pubmed:author | pubmed-author:NagarkattiMit... | lld:pubmed |
| pubmed-article:15146310 | pubmed:author | pubmed-author:CamachoIris... | lld:pubmed |
| pubmed-article:15146310 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15146310 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:15146310 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15146310 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15146310 | pubmed:pagination | 290-300 | lld:pubmed |
| pubmed-article:15146310 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:meshHeading | pubmed-meshheading:15146310... | lld:pubmed |
| pubmed-article:15146310 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15146310 | pubmed:articleTitle | Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on maternal immune response during pregnancy. | lld:pubmed |
| pubmed-article:15146310 | pubmed:affiliation | Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA. | lld:pubmed |
| pubmed-article:15146310 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15146310 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15146310 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15146310 | lld:pubmed |
