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pubmed-article:15115904pubmed:abstractTextHeart failure (HF) treatment guidelines of the ESC recommend ACE-inhibitors (ACE-I) as first-line treatment and beta-blockers added if patients remain symptomatic. CARMEN explored the need for combined treatment for remodelling and order of introduction by comparing the ACE-I enalapril against carvedilol and their combination.lld:pubmed
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pubmed-article:15115904pubmed:articleTitleThe benefits of early combination treatment of carvedilol and an ACE-inhibitor in mild heart failure and left ventricular systolic dysfunction. The carvedilol and ACE-inhibitor remodelling mild heart failure evaluation trial (CARMEN).lld:pubmed
pubmed-article:15115904pubmed:affiliationSticares Cardiovascular Research Foundation, Rhoon, The Netherlands. w.j.remme@sticares.orglld:pubmed
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