| pubmed-article:15104121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15104121 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15104121 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:15104121 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15104121 | lifeskim:mentions | umls-concept:C1539089 | lld:lifeskim |
| pubmed-article:15104121 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:15104121 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15104121 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:15104121 | pubmed:dateCreated | 2004-4-23 | lld:pubmed |
| pubmed-article:15104121 | pubmed:abstractText | Natural killer cell functions are regulated by signals through activating and inhibitory receptors. These receptors belong to the immunoglobulin superfamily or the lectin superfamily. We have previously identified a lectin-like transcript, LLT1, expressed in human NK cells. In the present study, we have generated a monoclonal antibody, L9.7, that specifically binds LLT1 receptor and studied the functional role of LLT1 in human NK cells. Binding of mAb L9.7 to surface LLT1 induced IFN-gamma production, but did not modulate cytotoxicity by YT cells, a human NK cell line. We further demonstrate that in resting NK cells as well as in IL-2 activated NK cells LLT1 induced IFN-gamma production, but not cytotoxicity. Excess amounts of L9.7 mAb failed to increase natural or antibody-dependent cell-mediated cytolytic activity, whereas minimal amounts achieved maximal production of IFN-gamma by YT and activated NK cells. These findings further support the separation of signaling pathways that regulate cytotoxicity and IFN-gamma production in resting as well as activated NK cells. | lld:pubmed |
| pubmed-article:15104121 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15104121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15104121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15104121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15104121 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15104121 | pubmed:issn | 0161-5890 | lld:pubmed |
| pubmed-article:15104121 | pubmed:author | pubmed-author:KumaresanPapp... | lld:pubmed |
| pubmed-article:15104121 | pubmed:author | pubmed-author:ChuangSamuel... | lld:pubmed |
| pubmed-article:15104121 | pubmed:author | pubmed-author:MathewPorunel... | lld:pubmed |
| pubmed-article:15104121 | pubmed:author | pubmed-author:VaidyaSwapnil... | lld:pubmed |
| pubmed-article:15104121 | pubmed:author | pubmed-author:BolesKent SKS | lld:pubmed |
| pubmed-article:15104121 | pubmed:author | pubmed-author:PhamHoang-Tua... | lld:pubmed |
| pubmed-article:15104121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15104121 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:15104121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15104121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15104121 | pubmed:pagination | 1157-63 | lld:pubmed |
| pubmed-article:15104121 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:meshHeading | pubmed-meshheading:15104121... | lld:pubmed |
| pubmed-article:15104121 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15104121 | pubmed:articleTitle | The LLT1 receptor induces IFN-gamma production by human natural killer cells. | lld:pubmed |
| pubmed-article:15104121 | pubmed:affiliation | Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699, USA. pmathew@hsc.unt.edu | lld:pubmed |
| pubmed-article:15104121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15104121 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:29121 | entrezgene:pubmed | pubmed-article:15104121 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15104121 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15104121 | lld:pubmed |
