| pubmed-article:15095143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0036563 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C1475832 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0017950 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0022947 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:15095143 | lifeskim:mentions | umls-concept:C0175727 | lld:lifeskim |
| pubmed-article:15095143 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15095143 | pubmed:dateCreated | 2004-4-19 | lld:pubmed |
| pubmed-article:15095143 | pubmed:abstractText | While searching for new estrogenic compounds from the plant kingdom, we investigated an extract of the seeds of Cuscuta chinensis (Convolvulaceae) which showed potency for stimulating MCF-7 cell proliferation. A novel resin glycoside, cuscutic resinoside A ( 6) was isolated along with five known compounds from the extract. The structure was deduced from its spectral data as (11 S)-hydroxyhexadecanoic acid 11- O-alpha- L-(4- O-2 R,3 R-nilylrhamnopyranosyl)-(1-->2)- O-alpha- L-rhamnopyranosyl-(1,2-lactone) forming a unique 15-membered macrocyclic lactone. The compound significantly stimulated not only MCF-7 cell proliferation but also T47D human breast cancer cells at a concentration of 10 microM. Along with cuscutamine ( 1) and kaempferol ( 4), 6 was tested in the transient luciferase reporter assay and was found to have different luciferase inducing activity characteristics from the other compounds. These results suggest that 6 stimulated cancer cell proliferation by a different mechanism from 1 and 4. | lld:pubmed |
| pubmed-article:15095143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15095143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15095143 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15095143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15095143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15095143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15095143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15095143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15095143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15095143 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15095143 | pubmed:issn | 0032-0943 | lld:pubmed |
| pubmed-article:15095143 | pubmed:author | pubmed-author:NoguchiHirosh... | lld:pubmed |
| pubmed-article:15095143 | pubmed:author | pubmed-author:DegawaMasakun... | lld:pubmed |
| pubmed-article:15095143 | pubmed:author | pubmed-author:MiyaseToshioT | lld:pubmed |
| pubmed-article:15095143 | pubmed:author | pubmed-author:NemotoKiyomit... | lld:pubmed |
| pubmed-article:15095143 | pubmed:author | pubmed-author:UmeharaKaoruK | lld:pubmed |
| pubmed-article:15095143 | pubmed:author | pubmed-author:OhkuboTsutomu... | lld:pubmed |
| pubmed-article:15095143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15095143 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:15095143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15095143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15095143 | pubmed:pagination | 299-304 | lld:pubmed |
| pubmed-article:15095143 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:meshHeading | pubmed-meshheading:15095143... | lld:pubmed |
| pubmed-article:15095143 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15095143 | pubmed:articleTitle | Isolation of a new 15-membered macrocyclic glycolipid lactone, Cuscutic Resinoside a from the seeds of Cuscuta chinensis: a stimulator of breast cancer cell proliferation. | lld:pubmed |
| pubmed-article:15095143 | pubmed:affiliation | School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. umehara@ys7.u-shizuoka-ken.ac.jp | lld:pubmed |
| pubmed-article:15095143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15095143 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
