| pubmed-article:15073177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C1333930 | lld:lifeskim |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C1427233 | lld:lifeskim |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15073177 | lifeskim:mentions | umls-concept:C0170509 | lld:lifeskim |
| pubmed-article:15073177 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:15073177 | pubmed:dateCreated | 2004-6-21 | lld:pubmed |
| pubmed-article:15073177 | pubmed:abstractText | Deregulation of c-myc expression is implicated in the pathogenesis of many neoplasias. Estrogen receptor alpha (ERalpha) can increase the rate of c-myc transcription through the recruitment of a variety of cofactors to the promoter, yet the precise roles of these cofactors in transcription and tumorigenesis are largely unknown. We show here that a putative tumor suppressor TIP30, also called CC3 or Htatip2, interacts with an ERalpha-interacting coactivator CIA. Using chromatin immunoprecipitation assays, we demonstrate that TIP30 and CIA are distinct cofactors that are dynamically associated with the promoter and downstream regions of the c-myc gene in response to estrogen. Both TIP30 and CIA are recruited to the c-myc gene promoter by liganded ERalpha in the second transcription cycle. TIP30 overexpression represses ERalpha-mediated c-myc transcription, whereas TIP30 deficiency enhances c-myc transcription in both the absence and presence of estrogen. Ectopic CIA cooperates with TIP30 to repress ERalpha-mediated c-myc transcription. Moreover, virgin TIP30 knockout mice exhibit increased c-myc expression in mammary glands. Together, these results reveal an important role for TIP30 in the regulation of ERalpha-mediated c-myc transcription and suggest a mechanism for tumorigenesis promoted by TIP30 deficiency. | lld:pubmed |
| pubmed-article:15073177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15073177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15073177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15073177 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15073177 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15073177 | pubmed:author | pubmed-author:RoederRobert... | lld:pubmed |
| pubmed-article:15073177 | pubmed:author | pubmed-author:XiaoHuaH | lld:pubmed |
| pubmed-article:15073177 | pubmed:author | pubmed-author:JiangChaoC | lld:pubmed |
| pubmed-article:15073177 | pubmed:author | pubmed-author:ItoMitsuhiroM | lld:pubmed |
| pubmed-article:15073177 | pubmed:author | pubmed-author:PieningValeri... | lld:pubmed |
| pubmed-article:15073177 | pubmed:author | pubmed-author:BruckKristyK | lld:pubmed |
| pubmed-article:15073177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15073177 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:15073177 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15073177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15073177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15073177 | pubmed:pagination | 27781-9 | lld:pubmed |
| pubmed-article:15073177 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15073177 | pubmed:meshHeading | pubmed-meshheading:15073177... | lld:pubmed |
| pubmed-article:15073177 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15073177 | pubmed:articleTitle | TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. | lld:pubmed |
| pubmed-article:15073177 | pubmed:affiliation | Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha 68198-7696, USA. | lld:pubmed |
| pubmed-article:15073177 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15073177 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15073177 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15073177 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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