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pubmed-article:1507226pubmed:abstractTextTheoretical studies of the sequence-dependent conformation of B-DNA have been carried out using Jumna, a helicoidal co-ordinate minimization algorithm. The results obtained for a series of six oligomers with repetitive sequences show that, with the exception of the homopolymers (dA)n.(dT)n and (dG)n.(dC)n, all sequences can adopt a variety of conformations characterized by considerable changes in helicoidal parameters and also in sugar puckers which adopt C(2')-endo (falling into 2 classes) or, in the case of pyrimidine nucleotides, O(1')-endo forms. These studies lead to an improved understanding of the role of base sequence on DNA conformation and point to a number of interesting correlations between the various structural parameters describing the double helix.lld:pubmed
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pubmed-article:1507226pubmed:articleTitleConformational sub-states in B-DNA.lld:pubmed
pubmed-article:1507226pubmed:affiliationLaboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, Paris, France.lld:pubmed
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