Linked Life Data

15071110

Source:http://linkedlifedata.com/resource/pubmed/id/15071110

Statements in which the resource exists.
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pubmed-article:15071110pubmed:abstractTextIt is generally believed that long-term potentiation (LTP) at hippocampal mossy fiber synapses between dentate granule and CA3 pyramidal cells is expressed through presynaptic mechanisms leading to an increase in quantal content. The source of this increase has remained undefined but could include enhanced probability of transmitter release at existing functional release sites or increases in the number of active release sites. We performed optical quantal analyses of transmission at individual mossy fiber synapses in cultured hippocampal slices, using confocal microscopy and intracellular fluorescent Ca(2+) indicators. Our results indicate that LTP is expressed at functional synapses by both increased probability of transmitter release and recruitment of new release sites, including the activation of previously silent synapses here visualized for the first time.lld:pubmed
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pubmed-article:15071110pubmed:authorpubmed-author:TakahashiMich...lld:pubmed
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pubmed-article:15071110pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15071110pubmed:articleTitleOptical quantal analysis indicates that long-term potentiation at single hippocampal mossy fiber synapses is expressed through increased release probability, recruitment of new release sites, and activation of silent synapses.lld:pubmed
pubmed-article:15071110pubmed:affiliationDivision of Neurophysiology, National Institute for Medical Research, London NW7 1AA, United Kingdom.lld:pubmed
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pubmed-article:15071110pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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