| pubmed-article:15070759 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C1273518 | lld:lifeskim |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15070759 | lifeskim:mentions | umls-concept:C2698594 | lld:lifeskim |
| pubmed-article:15070759 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:15070759 | pubmed:dateCreated | 2004-4-8 | lld:pubmed |
| pubmed-article:15070759 | pubmed:abstractText | CD4+CD25+ regulatory T cells are essential in the protection from organ-specific autoimmune diseases. In the pancreas, they inhibit actions of autoreactive T cells and thereby prevent diabetes progression. The signals that control the generation, the maintenance, or the expansion of regulatory T cell pool in vivo remain poorly understood. Here we show that a transient pulse of transforming growth factor beta (TGF-beta) in the islets during the priming phase of diabetes is sufficient to inhibit disease onset by promoting the expansion of intraislet CD4+CD25+ T cell pool. Approximately 40-50% of intraislet CD4+ T cells expressed the CD25 marker and exhibited characteristics of regulatory T cells including small size, high level of intracellular CTLA-4, expression of Foxp3, and transfer of protection against diabetes. Results from in vivo incorporation of BrdUrd revealed that the generation of a high frequency of regulatory T cells in the islets is due to in situ expansion upon TGF-beta expression. Thus, these findings demonstrate a previously uncharacterized mechanism by which TGF-beta inhibits autoimmune diseases via regulation of the size of the CD4+CD25+ regulatory T cell pool in vivo. | lld:pubmed |
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| pubmed-article:15070759 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15070759 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15070759 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15070759 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15070759 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15070759 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15070759 | pubmed:author | pubmed-author:FlavellRichar... | lld:pubmed |
| pubmed-article:15070759 | pubmed:author | pubmed-author:GreenE... | lld:pubmed |
| pubmed-article:15070759 | pubmed:author | pubmed-author:PengYufengY | lld:pubmed |
| pubmed-article:15070759 | pubmed:author | pubmed-author:LaouarYasmina... | lld:pubmed |
| pubmed-article:15070759 | pubmed:author | pubmed-author:LiMing OMO | lld:pubmed |
| pubmed-article:15070759 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15070759 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15070759 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15070759 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15070759 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15070759 | pubmed:pagination | 4572-7 | lld:pubmed |
| pubmed-article:15070759 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15070759 | pubmed:meshHeading | pubmed-meshheading:15070759... | lld:pubmed |
| pubmed-article:15070759 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15070759 | pubmed:articleTitle | TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. | lld:pubmed |
| pubmed-article:15070759 | pubmed:affiliation | Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. | lld:pubmed |
