| pubmed-article:15051765 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15051765 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15051765 | lifeskim:mentions | umls-concept:C0524889 | lld:lifeskim |
| pubmed-article:15051765 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:15051765 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15051765 | pubmed:dateCreated | 2004-4-6 | lld:pubmed |
| pubmed-article:15051765 | pubmed:abstractText | T cells directed against minor histocompatibility antigens (mHags) might be responsible for eradication of hematological malignancies after allogeneic stem cell transplantation. We investigated whether transfer of T cell receptors (TCRs) directed against mHags, exclusively expressed on hematopoietic cells, could redirect virus-specific T cells toward antileukemic reactivity, without the loss of their original specificity. Generation of T cells with dual specificity may lead to survival of these TCR-transferred T cells for prolonged periods of time in vivo due to transactivation of the endogenous TCR of the tumor-reactive T cells by the latent presence of viral antigens. Furthermore, TCR transfer into restricted T cell populations, which are nonself reactive, will minimize the risk of autoimmunity. We demonstrate that cytomegalovirus (CMV)-specific T cells can be efficiently reprogrammed into leukemia-reactive T cells by transfer of TCRs directed against the mHag HA-2. HA-2-TCR-transferred CMV-specific T cells derived from human histocompatibility leukocyte antigen (HLA)-A2+ or HLA-A2- individuals exerted potent antileukemic as well as CMV reactivity, without signs of anti-HLA-A2 alloreactivity. The dual specificity of these mHag-specific, TCR-redirected virus-specific T cells opens new possibilities for the treatment of hematological malignancies of HLA-A2+ HA-2-expressing patients transplanted with HLA-A2-matched or -mismatched donors. | lld:pubmed |
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| pubmed-article:15051765 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15051765 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15051765 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15051765 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15051765 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15051765 | pubmed:author | pubmed-author:HeemskerkMirj... | lld:pubmed |
| pubmed-article:15051765 | pubmed:author | pubmed-author:WillemzeRoelR | lld:pubmed |
| pubmed-article:15051765 | pubmed:author | pubmed-author:FalkenburgJ... | lld:pubmed |
| pubmed-article:15051765 | pubmed:author | pubmed-author:KesterMichel... | lld:pubmed |
| pubmed-article:15051765 | pubmed:author | pubmed-author:HoogeboomManj... | lld:pubmed |
| pubmed-article:15051765 | pubmed:author | pubmed-author:HagedoornRena... | lld:pubmed |
| pubmed-article:15051765 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15051765 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:15051765 | pubmed:volume | 199 | lld:pubmed |
| pubmed-article:15051765 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15051765 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15051765 | pubmed:pagination | 885-94 | lld:pubmed |
| pubmed-article:15051765 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15051765 | pubmed:meshHeading | pubmed-meshheading:15051765... | lld:pubmed |
| pubmed-article:15051765 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15051765 | pubmed:articleTitle | Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer. | lld:pubmed |
| pubmed-article:15051765 | pubmed:affiliation | Department of Hematology, Leiden University Medical Center, C2-R, P.O. Box 9600, 2300 RC, Netherlands. m.h.m.heemskerk@lumc.nl | lld:pubmed |
| pubmed-article:15051765 | pubmed:publicationType | Journal Article | lld:pubmed |
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