| pubmed-article:15039368 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0132555 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15039368 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15039368 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15039368 | pubmed:dateCreated | 2004-3-24 | lld:pubmed |
| pubmed-article:15039368 | pubmed:abstractText | Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88(-/-) mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88(-/-) mice failed to control mycobacterial replication and rapidly succumbed. Moreover, expressions of interleukin 12, tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase 2 were markedly decreased in the knockout animals. These results argue that resistance to M. tuberculosis must depend on MyD88-dependent signals mediated by an as-yet-undetermined TLR or a combination of TLRs. | lld:pubmed |
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| pubmed-article:15039368 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15039368 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15039368 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15039368 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15039368 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:15039368 | pubmed:author | pubmed-author:FengCarl GCG | lld:pubmed |
| pubmed-article:15039368 | pubmed:author | pubmed-author:CheeverAllen... | lld:pubmed |
| pubmed-article:15039368 | pubmed:author | pubmed-author:HienySaraS | lld:pubmed |
| pubmed-article:15039368 | pubmed:author | pubmed-author:SherAlanA | lld:pubmed |
| pubmed-article:15039368 | pubmed:author | pubmed-author:ScangaCharles... | lld:pubmed |
| pubmed-article:15039368 | pubmed:author | pubmed-author:BaficaAndreA | lld:pubmed |
| pubmed-article:15039368 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15039368 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:15039368 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15039368 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15039368 | pubmed:pagination | 2400-4 | lld:pubmed |
| pubmed-article:15039368 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15039368 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15039368 | pubmed:articleTitle | MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. | lld:pubmed |
| pubmed-article:15039368 | pubmed:affiliation | Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. cscanga@miaid.nih.gov | lld:pubmed |
| pubmed-article:15039368 | pubmed:publicationType | Journal Article | lld:pubmed |
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