| pubmed-article:15039315 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15039315 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:15039315 | lifeskim:mentions | umls-concept:C0027361 | lld:lifeskim |
| pubmed-article:15039315 | lifeskim:mentions | umls-concept:C0006849 | lld:lifeskim |
| pubmed-article:15039315 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:15039315 | lifeskim:mentions | umls-concept:C0052059 | lld:lifeskim |
| pubmed-article:15039315 | lifeskim:mentions | umls-concept:C0442040 | lld:lifeskim |
| pubmed-article:15039315 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15039315 | pubmed:dateCreated | 2004-3-24 | lld:pubmed |
| pubmed-article:15039315 | pubmed:abstractText | Oropharyngeal candidiasis, typically caused by Candida albicans, is the most common oral disease associated with human immunodeficiency virus type 1 (HIV-1) infection. Secretory leukocyte protease inhibitor (SLPI), a 12-kDa antiprotease, suppresses the growth of C. albicans in vitro. To determine whether the mucosal protein plays a role in protecting oral tissues against fungal infection, we conducted a cross-sectional study investigating the oral and systemic health and salivary SLPI levels in 91 dentate HIV-1-infected adults receiving medical care in the southeastern United States. Participants with a self-reported history of clinical oropharyngeal candidiasis during the previous 2 years constituted the test group (n = 52), while the comparison group (n = 39) had no oropharyngeal candidiasis during that period. Data collected from medical records, oral examination, and SLPI enzyme-linked immunosorbent assay quantitation of whole saliva were analyzed by t test, analysis of variance, linear regression, and unconditional logistic regression. The test group had a significantly higher mean salivary SLPI level than the comparison group (1.9 microg/ml versus 1.1 microg/ml, P < 0.05). Linear regression modeling identified CD4 cell count and history of oropharyngeal candidiasis as key predictors of salivary SLPI and revealed a significant interaction (P < 0.05) between immunosuppression (CD4 cell count below 200 cells/ microl) and positive history of oropharyngeal candidiasis in predicting salivary SLPI level. By logistic regression modeling, a salivary SLPI level exceeding 2.1 microg/ml, low CD4 count, antiretroviral monotherapy, and smoking were key predictors of oropharyngeal candidiasis. These data support a key role for SLPI in the oral mucosal defense against C. albicans. The antimicrobial mucosal protein may serve as an indicator of previous oropharyngeal candidiasis infection among immunosuppressed persons. | lld:pubmed |
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| pubmed-article:15039315 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15039315 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15039315 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15039315 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:15039315 | pubmed:author | pubmed-author:PattonLauren... | lld:pubmed |
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| pubmed-article:15039315 | pubmed:author | pubmed-author:TienHsaio-Chu... | lld:pubmed |
| pubmed-article:15039315 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15039315 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:15039315 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15039315 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15039315 | pubmed:pagination | 1956-63 | lld:pubmed |
| pubmed-article:15039315 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15039315 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15039315 | pubmed:articleTitle | Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. | lld:pubmed |
| pubmed-article:15039315 | pubmed:affiliation | School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. | lld:pubmed |
| pubmed-article:15039315 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15039315 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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