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pubmed-article:15026050pubmed:abstractTextThe effect of methanesulfonamide (MeSO(2)NH) group on COX-2 inhibitory activity of 1,5-diarylpyrazole is described. While this group being at position-4 of the N(1)-phenyl ring was found to be ineffective, its installation at position-4 of the C-5 phenyl ring offered several potent and selective inhibitors of COX-2 with IC(50) as low as 30 nM.lld:pubmed
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pubmed-article:15026050pubmed:articleTitleMethanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.lld:pubmed
pubmed-article:15026050pubmed:affiliationDiscovery Chemistry, Discovery Research-Dr Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, India. sunilkumarsingh@drredys.comlld:pubmed
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