| pubmed-article:15001984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0812201 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C1335858 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0076088 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0221928 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C0919432 | lld:lifeskim |
| pubmed-article:15001984 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15001984 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15001984 | pubmed:dateCreated | 2004-3-5 | lld:pubmed |
| pubmed-article:15001984 | pubmed:abstractText | In cultured human dermal fibroblasts, transforming growth factor (TGF)-beta induced the mRNA expression of tenascin-C (TN-C). The molecular mechanism(s) underlying this process is not presently understood. In this study, we performed serial 5' deletion and a transient transfection analysis to define a region in the TN-C promoter mediating the inducible responsiveness to TGF-beta. This region contains an atypical nucleotide recognition element for the Smad family of transcriptional regulators. A DNA affinity precipitation assay revealed that Smad2/Smad3 bound to this site in a transient and specific manner. Overexpression of Smad3 or Smad4 activated the TN-C promoter activity and superinduced the TN-C promoter activity stimulated by TGF-beta. Moreover, simultaneous cotransfection of Smad3 and Smad4 activated the TN-C promoter activity in a synergistic manner. Mutation of the Smad-binding sites, the Ets-binding sites, or Sp1/3-binding sites in the TN-C promoter abrogated the TGF-beta/Smad-inducible promoter activity. Immunoprecipitation analysis revealed that Smad3, Sp1, and Ets1 form a transcriptionally active complex. Furthermore, the interaction between Smads and CBP/p300 in TGF-beta signaling was confirmed. These findings demonstrate the existence of a novel, functional binding element in the proximal region of the TN-C promoter mediating responsiveness to TGF-beta involving Smad3/4, Sp1, Ets1, and CBP/p300. | lld:pubmed |
| pubmed-article:15001984 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15001984 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15001984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15001984 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15001984 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:15001984 | pubmed:author | pubmed-author:IhnHironobuH | lld:pubmed |
| pubmed-article:15001984 | pubmed:author | pubmed-author:YamaneKenichi... | lld:pubmed |
| pubmed-article:15001984 | pubmed:author | pubmed-author:AsanoYoshihid... | lld:pubmed |
| pubmed-article:15001984 | pubmed:author | pubmed-author:TamakiKunihik... | lld:pubmed |
| pubmed-article:15001984 | pubmed:author | pubmed-author:TrojanowskaMa... | lld:pubmed |
| pubmed-article:15001984 | pubmed:author | pubmed-author:JinninMasatos... | lld:pubmed |
| pubmed-article:15001984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15001984 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:15001984 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:15001984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15001984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15001984 | pubmed:pagination | 1656-67 | lld:pubmed |
| pubmed-article:15001984 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15001984 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15001984 | pubmed:articleTitle | Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. | lld:pubmed |
| pubmed-article:15001984 | pubmed:affiliation | Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. | lld:pubmed |
| pubmed-article:15001984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15001984 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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