| pubmed-article:1499719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0027468 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0033554 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0003695 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0031671 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0300926 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1499719 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1499719 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1499719 | pubmed:dateCreated | 1992-9-16 | lld:pubmed |
| pubmed-article:1499719 | pubmed:abstractText | Over-expression of human phospholipase C-gamma 2 in murine NIH 3T3 fibroblasts has been shown to result in an increased platelet-derived growth factor-mediated formation of inositol phosphates. Here we show that phospholipase C-gamma 2 over-expression is associated with an increased platelet-derived growth factor-mediated release of arachidonic acid, prostaglandin E2, 6-keto prostaglandin F1 alpha and prostaglandin F2 alpha. The phorbol ester, calcium ionophore- and fluoride-induced release of arachidonate and its metabolites is not affected by phospholipase C-gamma 2 over-expression. Over-expression of phospholipase C-gamma 2 is also associated with an enhancement of platelet-derived growth factor-induced change in intracellular Ca2+. These results demonstrate that stimulation of recombinant human phospholipase C-gamma 2 induces a change in the intracellular Ca2+ concentration, a release of arachidonic acid and formation of prostaglandins in NIH 3T3 cells. In control cells platelet-derived growth factor-induced activation of arachidonic acid cascade is rate-limited by the endogenous phospholipase C. | lld:pubmed |
| pubmed-article:1499719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1499719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1499719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1499719 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1499719 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:1499719 | pubmed:author | pubmed-author:FitzkeEE | lld:pubmed |
| pubmed-article:1499719 | pubmed:author | pubmed-author:HugHH | lld:pubmed |
| pubmed-article:1499719 | pubmed:author | pubmed-author:MarméDD | lld:pubmed |
| pubmed-article:1499719 | pubmed:author | pubmed-author:TotzkeFF | lld:pubmed |
| pubmed-article:1499719 | pubmed:author | pubmed-author:DieterPP | lld:pubmed |
| pubmed-article:1499719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1499719 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:1499719 | pubmed:volume | 308 | lld:pubmed |
| pubmed-article:1499719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1499719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1499719 | pubmed:pagination | 125-9 | lld:pubmed |
| pubmed-article:1499719 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
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| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
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| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
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| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
| pubmed-article:1499719 | pubmed:meshHeading | pubmed-meshheading:1499719-... | lld:pubmed |
| pubmed-article:1499719 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1499719 | pubmed:articleTitle | Over-expression of human phospholipase C-gamma 2 enhances platelet-derived growth factor-induced mobilization of intracellular Ca2+ and the release of arachidonic acid and prostaglandins in NIH 3T3 fibroblasts. | lld:pubmed |
| pubmed-article:1499719 | pubmed:affiliation | University of Freiburg, Institute of Molecular Cell Biology, Gödecke AG, Germany. | lld:pubmed |
| pubmed-article:1499719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1499719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1499719 | lld:pubmed |
