| pubmed-article:14982996 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14982996 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14982996 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:14982996 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:14982996 | lifeskim:mentions | umls-concept:C0669472 | lld:lifeskim |
| pubmed-article:14982996 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:14982996 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:14982996 | pubmed:dateCreated | 2004-2-25 | lld:pubmed |
| pubmed-article:14982996 | pubmed:abstractText | The family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a variety of cellular processes. The human genome contains many putative USP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity, and substrate specificity. We have used a chemistry-based functional proteomics approach to identify active USPs in normal, virus-infected, and tumor-derived human cells. Depending on tissue origin and stage of activation/differentiation, different USP activity profiles were revealed. The activity of specific USPs, including USP5, -7, -9, -13, -15, and -22, was up-regulated by mitogen activation or virus infection in normal T and B lymphocytes. UCH-L1 was highly expressed in tumor cell lines of epithelial and hematopoietic cell origin but was not detected in freshly isolated and mitogen-activated cells. Up-regulation of this USP was a late event in the establishment of Epstein-Barr virus-immortalized lymphoblastoid cell lines and correlated with enhanced proliferation, suggesting a possible role in growth transformation. | lld:pubmed |
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| pubmed-article:14982996 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14982996 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14982996 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14982996 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14982996 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14982996 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:14982996 | pubmed:author | pubmed-author:PloeghHidde... | lld:pubmed |
| pubmed-article:14982996 | pubmed:author | pubmed-author:MasucciMaria... | lld:pubmed |
| pubmed-article:14982996 | pubmed:author | pubmed-author:KesslerBenedi... | lld:pubmed |
| pubmed-article:14982996 | pubmed:author | pubmed-author:OvaaHuibH | lld:pubmed |
| pubmed-article:14982996 | pubmed:author | pubmed-author:GalardyPaul... | lld:pubmed |
| pubmed-article:14982996 | pubmed:author | pubmed-author:RolénUlrikaU | lld:pubmed |
| pubmed-article:14982996 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14982996 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:14982996 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:14982996 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14982996 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14982996 | pubmed:pagination | 2253-8 | lld:pubmed |
| pubmed-article:14982996 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14982996 | pubmed:meshHeading | pubmed-meshheading:14982996... | lld:pubmed |
| pubmed-article:14982996 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14982996 | pubmed:articleTitle | Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. | lld:pubmed |
| pubmed-article:14982996 | pubmed:affiliation | Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:14982996 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14982996 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14982996 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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