| pubmed-article:14978754 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14978754 | lifeskim:mentions | umls-concept:C0079679 | lld:lifeskim |
| pubmed-article:14978754 | lifeskim:mentions | umls-concept:C0079337 | lld:lifeskim |
| pubmed-article:14978754 | lifeskim:mentions | umls-concept:C0206037 | lld:lifeskim |
| pubmed-article:14978754 | pubmed:dateCreated | 2004-2-23 | lld:pubmed |
| pubmed-article:14978754 | pubmed:abstractText | Molecular virological understanding of the feline immunodeficiency virus (FIV) life cycle is increasing, facilitating rational derivation of improved vectors from this non-primate lentivirus. The packaging signal has been mapped, a central DNA flap has been identified, and class I integrase mutants have been validated. Vector systems with improved effectiveness and safety profiles are being applied by a number of laboratories in several pre-clinical models, with demonstrated efficacy in human tissues. The comparative lentivirological research that facilitates FIV vector development may also yield insights into the still enigmatic molecular basis for a signature lentiviral property with pathogenetic and therapeutic importance: permanent transgene integration in non-dividing cells. This review discusses virological aspects of lentiviral vector development, as well as some recent controversies and applications. | lld:pubmed |
| pubmed-article:14978754 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978754 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14978754 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14978754 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14978754 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14978754 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14978754 | pubmed:issn | 1099-498X | lld:pubmed |
| pubmed-article:14978754 | pubmed:author | pubmed-author:PoeschlaEric... | lld:pubmed |
| pubmed-article:14978754 | pubmed:author | pubmed-author:SaenzDyana... | lld:pubmed |
| pubmed-article:14978754 | pubmed:copyrightInfo | Copyright 2004 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:14978754 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14978754 | pubmed:volume | 6 Suppl 1 | lld:pubmed |
| pubmed-article:14978754 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14978754 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14978754 | pubmed:pagination | S95-104 | lld:pubmed |
| pubmed-article:14978754 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:meshHeading | pubmed-meshheading:14978754... | lld:pubmed |
| pubmed-article:14978754 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14978754 | pubmed:articleTitle | FIV: from lentivirus to lentivector. | lld:pubmed |
| pubmed-article:14978754 | pubmed:affiliation | Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. | lld:pubmed |
| pubmed-article:14978754 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14978754 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14978754 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:14978754 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14978754 | lld:pubmed |
