| pubmed-article:1494939 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C0007450 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C0026973 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C0037925 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C0028246 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:1494939 | lifeskim:mentions | umls-concept:C1704788 | lld:lifeskim |
| pubmed-article:1494939 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1494939 | pubmed:dateCreated | 1992-9-4 | lld:pubmed |
| pubmed-article:1494939 | pubmed:abstractText | This study analyzes the synaptic interactions between the central terminals of A delta high threshold mechanoreceptors (A delta HTMs) and GABA-immunoreactive profiles. A delta HTM primary afferents from three monkeys and one cat were electrophysiologically identified and intracellularly labeled with HRP, and their terminal arborizations in laminae I and II of the sacrocaudal spinal cord were studied at the ultrastructural level. GABA-immunoreactive profiles in relation to A delta HTM terminals were demonstrated using postembedding colloidal gold techniques. Monkey A delta HTM terminals (n = 131) usually constituted the central element of synaptic glomeruli; they established large asymmetric synaptic contacts with 1-13 dendrites (modal value 2-4) and were surrounded by 0-6 peripheral axon terminals (modal value 2-3). The large majority (around 85%) of the peripheral axon terminals were GABA immunoreactive. They were found presynaptic to the A delta HTM terminal and/or to dendrites postsynaptic to the primary afferent terminal. Furthermore, all peripheral axon terminals found presynaptic to the A delta HTM terminals showed GABA immunoreactivity. Within a single A delta HTM fiber, this synaptic arrangement was found in 20-60% of its boutons. In addition, 28% of the postsynaptic dendritic profiles displayed weak GABA immunoreactivity. Some of them contained vesicles; however, only in a few cases did we observe synapses between a GABA-immunoreactive vesicle-containing dendrite and a dendritic profile postsynaptic to an A delta HTM terminal. Similar synaptology and interactions with GABA-immunoreactive profiles were displayed by the terminals of the single cat A delta HTM fiber studied. Our data support the hypothesis that GABA-containing neurons use both presynaptic and/or postsynaptic mechanisms to exert a powerful control, presumably inhibitory, over the transmission of nociceptive information between A delta HTM afferents and second-order neurons in monkey and cat spinal cord. Our results also imply that GABA may be released within the synaptic glomeruli formed by A delta HTM terminals either by local dendrites or by axon terminals. We discuss the possibility that these GABAergic synapses can be driven by inputs from both primary afferents and/or descending systems to modulate the transmission of nociceptive sensory information. | lld:pubmed |
| pubmed-article:1494939 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494939 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494939 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494939 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1494939 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494939 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1494939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1494939 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1494939 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1494939 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:1494939 | pubmed:author | pubmed-author:LightA RAR | lld:pubmed |
| pubmed-article:1494939 | pubmed:author | pubmed-author:KavookjianA... | lld:pubmed |
| pubmed-article:1494939 | pubmed:author | pubmed-author:AlvarezF JFJ | lld:pubmed |
| pubmed-article:1494939 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1494939 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1494939 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1494939 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1494939 | pubmed:pagination | 2901-17 | lld:pubmed |
| pubmed-article:1494939 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:meshHeading | pubmed-meshheading:1494939-... | lld:pubmed |
| pubmed-article:1494939 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1494939 | pubmed:articleTitle | Synaptic interactions between GABA-immunoreactive profiles and the terminals of functionally defined myelinated nociceptors in the monkey and cat spinal cord. | lld:pubmed |
| pubmed-article:1494939 | pubmed:affiliation | Department of Physiology, School of Medicine, University of North Carolina, Chapel Hill 27599. | lld:pubmed |
| pubmed-article:1494939 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1494939 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1494939 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1494939 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1494939 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1494939 | lld:pubmed |
