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pubmed-article:14871399pubmed:abstractTextHuman colon contains many bacteria that commonly colonize the perineum and frequently enter the urinary tract. Uropathogenic Escherichia coli are the most common cause of urinary tract infection. Type 1 fimbriated E. coli have been associated with cystitis, and P fimbriated E. coli with pyelonephritis. Factors involved in clearing bacteria from the urinary tract are poorly understood. Tamm-Horsfall protein (THP), the most abundant protein in mammalian urine, has been postulated to play a role in defense against urinary tract infection but definitive proof for this idea has been lacking.lld:pubmed
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pubmed-article:14871399pubmed:articleTitleTamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.lld:pubmed
pubmed-article:14871399pubmed:affiliationDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.lld:pubmed
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