| pubmed-article:1480550 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1480550 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:1480550 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:1480550 | lifeskim:mentions | umls-concept:C0020365 | lld:lifeskim |
| pubmed-article:1480550 | lifeskim:mentions | umls-concept:C0003289 | lld:lifeskim |
| pubmed-article:1480550 | lifeskim:mentions | umls-concept:C0011685 | lld:lifeskim |
| pubmed-article:1480550 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1480550 | pubmed:dateCreated | 1993-2-5 | lld:pubmed |
| pubmed-article:1480550 | pubmed:abstractText | Incubation of the tricyclic antidepressant desmethylimpramine (DMI) with rat liver or brain microsomes in the presence of NADPH or t-butyl-hydroperoxide (TBH) revealed different regiospecificities in the hydroxylation reactions between the tissues. In brain preparations 10-OH-DMI was formed in reactions supported by NADPH or TBH, whereas in the latter case also an unidentified metabolite could be detected. Inclusion of exogenous NADPH-cytochrome P450 reductase in the brain preparations caused a 10-fold higher rate of 10-hydroxylation but no 2-OH-DMI could be detected. By contrast, liver microsomal preparations in the presence of NADPH catalyzed formation of both 2- and 10-OH-DMI, whereas only 10-OH-DMI was formed in TBH-supported reactions. The results indicate that antidepressant drugs can be metabolized in brain with different stereospecificity as compared to liver. | lld:pubmed |
| pubmed-article:1480550 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1480550 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1480550 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1480550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1480550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1480550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1480550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1480550 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1480550 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1480550 | pubmed:issn | 0901-9928 | lld:pubmed |
| pubmed-article:1480550 | pubmed:author | pubmed-author:von BahrCC | lld:pubmed |
| pubmed-article:1480550 | pubmed:author | pubmed-author:HanssonTT | lld:pubmed |
| pubmed-article:1480550 | pubmed:author | pubmed-author:Ingelman-Sund... | lld:pubmed |
| pubmed-article:1480550 | pubmed:author | pubmed-author:SvenssonJ OJO | lld:pubmed |
| pubmed-article:1480550 | pubmed:author | pubmed-author:LundströmJJ | lld:pubmed |
| pubmed-article:1480550 | pubmed:author | pubmed-author:MarklundMM | lld:pubmed |
| pubmed-article:1480550 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1480550 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:1480550 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1480550 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1480550 | pubmed:pagination | 416-9 | lld:pubmed |
| pubmed-article:1480550 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:meshHeading | pubmed-meshheading:1480550-... | lld:pubmed |
| pubmed-article:1480550 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1480550 | pubmed:articleTitle | Different regiospecificity in the hydroxylation of the antidepressant desmethylimipramine between rat brain and liver. | lld:pubmed |
| pubmed-article:1480550 | pubmed:affiliation | Department of Drug Metabolism, Astra Research Centre, Södertälje, Sweden. | lld:pubmed |
| pubmed-article:1480550 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1480550 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1480550 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1480550 | lld:pubmed |
