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pubmed-article:14744281pubmed:abstractTextO(6)-Methylguanine-deoxyribonucleic acid methyltransferase (MGMT) is a deoxyribonucleic acid repair protein associated with the chemoresistance of chloroethylnitrosoureas. We investigated whether MGMT promoter hypermethylation is associated with prognosis in patients with high-grade astrocytic tumors treated uniformly with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU)-based chemotherapy.lld:pubmed
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pubmed-article:14744281pubmed:pagination349-57; discussion 357lld:pubmed
pubmed-article:14744281pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:14744281pubmed:articleTitleCorrelation between promoter hypermethylation of the O6-methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea-based chemotherapy.lld:pubmed
pubmed-article:14744281pubmed:affiliationDepartment of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan. tkamiryo-nsu@umin.ac.jplld:pubmed
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