| pubmed-article:14738872 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0032285 | lld:lifeskim |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0085478 | lld:lifeskim |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:14738872 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:14738872 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14738872 | pubmed:dateCreated | 2004-1-23 | lld:pubmed |
| pubmed-article:14738872 | pubmed:abstractText | Aspiration pneumonia is a common cause of death in older people, and the pathophysiology is a chronic respiratory failure with a mild airway inflammation. In this study, we established a mild inflammatory pneumonia model using Porphyromonas gingivalis (Pg) pathogen-infected mice. It elucidated the effects of Pg-infected pneumonia on proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), and IL-1beta production in both lung tissue and serum. We also elucidated production of soluble (s) TNF receptor (R) s, because TNF-alpha is considered to be a dominant inflammatory mediator. Lung TNF-alpha levels significantly increased at 2 h after infection, and rapidly returned to basal level at 24 h. Consistent with increase of TNF-alpha, remarkable increase of sTNFR2 but not sTNFR1 was detected in lung tissue from 2 to 72 h. Interestingly, sTNFR2/sTNFR1 ratio was significantly enhanced at 2 h in serum. In addition, lung IL-1beta and IL-6 levels also significantly increased from 2 to 24 h. Importantly, we found that IL-6 levels in serum reflected its local level. These results may suggest that systemically produced sTNFR2 and IL-6 could be a key role to modulate proinflammatory activities of TNF-alpha in Pg-induced lung inflammation simulated aspiration pneumonia. | lld:pubmed |
| pubmed-article:14738872 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14738872 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14738872 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14738872 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14738872 | pubmed:issn | 0014-4800 | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:NishimuraFusa... | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:TakashibaShog... | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:MurayamaYojiY | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:NaruishiKojiK | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:MineshibaJunj... | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:AraiHideoH | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:ShiomiNobuyuk... | lld:pubmed |
| pubmed-article:14738872 | pubmed:author | pubmed-author:PetelinMilanM | lld:pubmed |
| pubmed-article:14738872 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14738872 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:14738872 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14738872 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14738872 | pubmed:pagination | 76-81 | lld:pubmed |
| pubmed-article:14738872 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14738872 | pubmed:meshHeading | pubmed-meshheading:14738872... | lld:pubmed |
| pubmed-article:14738872 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14738872 | pubmed:articleTitle | Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice. | lld:pubmed |
| pubmed-article:14738872 | pubmed:affiliation | Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8525, Japan. | lld:pubmed |
| pubmed-article:14738872 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14738872 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14738872 | lld:pubmed |
