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pubmed-article:14737979pubmed:dateCreated2004-1-23lld:pubmed
pubmed-article:14737979pubmed:abstractTextGlomerular filtration rate (GFR) is the best indicator of renal function. GFR is usually estimated by serum creatinine or the creatinine clearance calculated on urine collected over 24 hours or with the Cockcroft formula. These methods are however limited. Serum creatinine has a very poor sensitivity and urine collection is difficult. Cystatin C is a protease inhibitor produced in a constant manner by nucleated cells. This molecule is freely filtrated by the glomerule and quite completely catabolized in the proximal tubules. Its plasmatic concentration might thus be used to estimate GFR. Presently available data allow to conclude that plasmatic cystatin C is at least as good as serum creatinine to estimate GFR. It is less sensible to changes in body mass. Its determination appears more sensitive to detect early mild changes in GFR. Reference values are presently available for the different methods of determination. Cystatin C plasma level determination is more expensive than routine creatinine plasma determination. In the absence of very significant advantages, this might explain its limited use in daily clinical practice.lld:pubmed
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pubmed-article:14737979pubmed:authorpubmed-author:RoriveGGlld:pubmed
pubmed-article:14737979pubmed:authorpubmed-author:GielenJJlld:pubmed
pubmed-article:14737979pubmed:authorpubmed-author:ChapelleJ PJPlld:pubmed
pubmed-article:14737979pubmed:authorpubmed-author:KrzesinskiJ...lld:pubmed
pubmed-article:14737979pubmed:authorpubmed-author:DelanayePPlld:pubmed
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pubmed-article:14737979pubmed:volume24lld:pubmed
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pubmed-article:14737979pubmed:pagination457-68lld:pubmed
pubmed-article:14737979pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:14737979pubmed:year2003lld:pubmed
pubmed-article:14737979pubmed:articleTitle[Cystatin C in the evaluation of renal function].lld:pubmed
pubmed-article:14737979pubmed:affiliationService de néphrologie, CHU, Sart Tilman, Liège. pierre_stone@hotmail.comlld:pubmed
pubmed-article:14737979pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14737979pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:14737979pubmed:publicationTypeReviewlld:pubmed