Linked Life Data

14734045

Source:http://linkedlifedata.com/resource/pubmed/id/14734045

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pubmed-article:14734045pubmed:abstractText- The normal increase in isometric developed force (DF) with faster pacing rates, known as the positive force-frequency response/relationship (FFR), is altered in failing myocardium, as shown by its negative response to increased pacing. The objective of this study was to determine if increasing Ca2+ influx with L-type Ca2+ channel (L-CaCh) agonists: BayK 8644 (BayK) and FPL 64176 (FPL) or increased extracellular Ca2+ could increase contractility and normalize the FFR in failing myocardium.lld:pubmed
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pubmed-article:14734045pubmed:articleTitleAbnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium.lld:pubmed
pubmed-article:14734045pubmed:affiliationCardiovascular Research Group, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA. erossman@temple.edulld:pubmed
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