| pubmed-article:14724565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14724565 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:14724565 | lifeskim:mentions | umls-concept:C1335647 | lld:lifeskim |
| pubmed-article:14724565 | lifeskim:mentions | umls-concept:C0036387 | lld:lifeskim |
| pubmed-article:14724565 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:14724565 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:14724565 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14724565 | pubmed:dateCreated | 2004-1-15 | lld:pubmed |
| pubmed-article:14724565 | pubmed:abstractText | The neurofibromatosis type 1 tumor suppressor protein neurofibromin, is a GTPase activating protein for H-, N-, K-, R-Ras and TC21/R-Ras2 proteins. We demonstrate that Schwann cells derived from Nf1-null mice have enhanced chemokinetic and chemotactic migration in comparison to wild-type controls. Surprisingly, this migratory phenotype is not inhibited by a farnesyltransferase inhibitor or dominant-negative (dn) (N17)H-Ras (which inhibits H-, N-, and K-Ras activation). We postulated that increased activity of R-Ras and/or TC21/R-Ras2, due to loss of Nf1, contributes to increased migration. Mouse Schwann cells (MSCs) express R-Ras and TC21/R-Ras2 and their specific guanine exchange factors, C3G and AND-34. Infection of Nf1-null MSCs with a dn(43N)R-Ras adenovirus (to inhibit both R-Ras and TC21/R-Ras2 activation) decreases migration by approximately 50%. Conversely, expression of activated (72L)TC21/R-Ras2, but not activated (38V)R-Ras, increases migration, suggesting a role of TC21/R-Ras2 activation in the migration of neurofibromin-deficient Schwann cells. TC21/R-Ras2 preferentially couples to the phosphatidylinositol 3-kinase (PI3-kinase) and MAP kinase pathways. Treatment with a PI3-kinase or MAP kinase inhibitor reduces Nf1-null Schwann cell migration, implicating these TC21 effectors in Schwann cell migration. These data reveal a key role for neurofibromin regulation of TC21/R-Ras2 in Schwann cells, a cell type critical to NF1 tumor pathogenesis. | lld:pubmed |
| pubmed-article:14724565 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14724565 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14724565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14724565 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14724565 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:CoxAdrienne... | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:RatnerNancyN | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:KamholzJohnJ | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:HuangYuanY | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:RangwalaFatim... | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:FulkersonPatr... | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:LingBoB | lld:pubmed |
| pubmed-article:14724565 | pubmed:author | pubmed-author:ReedErinE | lld:pubmed |
| pubmed-article:14724565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14724565 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14724565 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:14724565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14724565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14724565 | pubmed:pagination | 368-78 | lld:pubmed |
