| pubmed-article:14706338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0118111 | lld:lifeskim |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0813145 | lld:lifeskim |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0887840 | lld:lifeskim |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14706338 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:14706338 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14706338 | pubmed:dateCreated | 2004-1-6 | lld:pubmed |
| pubmed-article:14706338 | pubmed:abstractText | The PI3K/PTEN/Akt signal transduction pathway plays a key role in many tumors. Downstream targets of this pathway include the Forkhead family of transcription factors (FOXO1a, FOXO3a, FOXO4). In PTEN null cells, FOXO1a is inactivated by PI3K-dependent phosphorylation and mislocalization to the cytoplasm, yet still undergoes nucleocytoplasmic shuttling. Since forcible localization of FOXO1a to the nucleus can reverse tumorigenicity of PTEN null cells, a high-content, chemical genetic screen for inhibitors of FOXO1a nuclear export was performed. The compounds detected in the primary screen were retested in secondary assays, and structure-function relationships were identified. Novel general export inhibitors were found that react with CRM1 as well as a number of compounds that inhibit PI3K/Akt signaling, among which are included multiple antagonists of calmodulin signaling. | lld:pubmed |
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| pubmed-article:14706338 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14706338 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14706338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14706338 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14706338 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:RobertsThomas... | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:SchroederFran... | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:ClardyJonJ | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:SilverPamela... | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:Wojciechowski... | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:SellersWillia... | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:RamaswamyShiv... | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:KauTweeny RTR | lld:pubmed |
| pubmed-article:14706338 | pubmed:author | pubmed-author:ZhaoJean JJJ | lld:pubmed |
| pubmed-article:14706338 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14706338 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:14706338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14706338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14706338 | pubmed:pagination | 463-76 | lld:pubmed |
| pubmed-article:14706338 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:14706338 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14706338 | pubmed:articleTitle | A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. | lld:pubmed |
| pubmed-article:14706338 | pubmed:affiliation | Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:14706338 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14706338 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14706338 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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