| pubmed-article:14702632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14702632 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:14702632 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:14702632 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:14702632 | lifeskim:mentions | umls-concept:C0279492 | lld:lifeskim |
| pubmed-article:14702632 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14702632 | pubmed:dateCreated | 2004-1-2 | lld:pubmed |
| pubmed-article:14702632 | pubmed:abstractText | Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy. This increase in androgen receptor mRNA and protein was both necessary and sufficient to convert prostate cancer growth from a hormone-sensitive to a hormone-refractory stage, and was dependent on a functional ligand-binding domain. Androgen receptor antagonists showed agonistic activity in cells with increased androgen receptor levels; this antagonist-agonist conversion was associated with alterations in the recruitment of coactivators and corepressors to the promoters of androgen receptor target genes. Increased levels of androgen receptor confer resistance to antiandrogens by amplifying signal output from low levels of residual ligand, and by altering the normal response to antagonists. These findings provide insight toward the design of new antiandrogens. | lld:pubmed |
| pubmed-article:14702632 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14702632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14702632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14702632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14702632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14702632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14702632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14702632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14702632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14702632 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14702632 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:SawyersCharle... | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:RosenfeldMich... | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:ChenCharlie... | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:VessellaRober... | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:BaekSung... | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:TranChrisC | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:WelsbieDerek... | lld:pubmed |
| pubmed-article:14702632 | pubmed:author | pubmed-author:ChenRandyR | lld:pubmed |
| pubmed-article:14702632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14702632 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:14702632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14702632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14702632 | pubmed:pagination | 33-9 | lld:pubmed |
| pubmed-article:14702632 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:meshHeading | pubmed-meshheading:14702632... | lld:pubmed |
| pubmed-article:14702632 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14702632 | pubmed:articleTitle | Molecular determinants of resistance to antiandrogen therapy. | lld:pubmed |
| pubmed-article:14702632 | pubmed:affiliation | Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA. | lld:pubmed |
| pubmed-article:14702632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14702632 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14702632 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:14702632 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14702632 | lld:pubmed |
