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pubmed-article:14698782pubmed:abstractTextPositron Emission Tomography was used to measure global and regional cardiac beta-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [(11)C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [(11)C]-CGP12177 was used to measure cell surface beta-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.lld:pubmed
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pubmed-article:14698782pubmed:articleTitlePET measures of pre- and post-synaptic cardiac beta adrenergic function.lld:pubmed
pubmed-article:14698782pubmed:affiliationDepartment of Radiology, Box 356004, University of Washington, Seattle, WA 98195, USA.lld:pubmed
pubmed-article:14698782pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:14698782pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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