| pubmed-article:14691223 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14691223 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:14691223 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:14691223 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:14691223 | lifeskim:mentions | umls-concept:C0242808 | lld:lifeskim |
| pubmed-article:14691223 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14691223 | pubmed:dateCreated | 2003-12-23 | lld:pubmed |
| pubmed-article:14691223 | pubmed:abstractText | Comparisons were made among four categories of protein flexibility: (1) low-B-factor ordered regions, (2) high-B-factor ordered regions, (3) short disordered regions, and (4) long disordered regions. Amino acid compositions of the four categories were found to be significantly different from each other, with high-B-factor ordered and short disordered regions being the most similar pair. The high-B-factor (flexible) ordered regions are characterized by a higher average flexibility index, higher average hydrophilicity, higher average absolute net charge, and higher total charge than disordered regions. The low-B-factor regions are significantly enriched in hydrophobic residues and depleted in the total number of charged residues compared to the other three categories. We examined the predictability of the high-B-factor regions and developed a predictor that discriminates between regions of low and high B-factors. This predictor achieved an accuracy of 70% and a correlation of 0.43 with experimental data, outperforming the 64% accuracy and 0.32 correlation of predictors based solely on flexibility indices. To further clarify the differences between short disordered regions and ordered regions, a predictor of short disordered regions was developed. Its relatively high accuracy of 81% indicates considerable differences between ordered and disordered regions. The distinctive amino acid biases of high-B-factor ordered regions, short disordered regions, and long disordered regions indicate that the sequence determinants for these flexibility categories differ from one another, whereas the significantly-greater-than-chance predictability of these categories from sequence suggest that flexible ordered regions, short disorder, and long disorder are, to a significant degree, encoded at the primary structure level. | lld:pubmed |
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| pubmed-article:14691223 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14691223 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14691223 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14691223 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14691223 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14691223 | pubmed:issn | 0961-8368 | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:GuppyI WIW | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:SmithDavid... | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:DunkerA... | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:LawsonJ... | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:RadivojacPred... | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:ObradovicZora... | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:BrownCeleste... | lld:pubmed |
| pubmed-article:14691223 | pubmed:author | pubmed-author:VuceticSlobod... | lld:pubmed |
| pubmed-article:14691223 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14691223 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:14691223 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14691223 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14691223 | pubmed:pagination | 71-80 | lld:pubmed |
| pubmed-article:14691223 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:14691223 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14691223 | pubmed:articleTitle | Protein flexibility and intrinsic disorder. | lld:pubmed |
| pubmed-article:14691223 | pubmed:affiliation | Center for Information Science and Technology, Temple University, Philadelphia, PA 19122, USA. | lld:pubmed |
| pubmed-article:14691223 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14691223 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14691223 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14691223 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:14691223 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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