| pubmed-article:14678196 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C1883036 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:14678196 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14678196 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14678196 | pubmed:dateCreated | 2003-12-17 | lld:pubmed |
| pubmed-article:14678196 | pubmed:abstractText | Two types of T helper (Th) cells - Th1 and Th2 - play different roles in protection and immunopathology. The Th1 cell-mediated immune response plays an important role in inducing the host defence against intracellular bacteria and also in cancer immunotherapy. To effectively induce Th1 immune responses, we constructed a mammalian expression plasmid (pAnti-CD3sFv/IL-18) carrying a fusion gene in which anti-CD3 single-chain Fv (sFv) cDNA, the smallest unit of antibody recognizing the CD3 epsilon moiety of the T-cell receptor, was covalently linked to mature interleukin (IL)-18 cDNA. Intramuscular injection of ovalbumin (OVA)-sensitized BALB/c mice with pAnti-CD3sFv/IL-18 DNA efficiently increased the production of both OVA-specific interferon-gamma and anti-OVA immunoglobulin G2a, compared to injection with pAnti-CD3sFv DNA. In addition, pAnti-CD3sFv/IL-18 was more efficient than a mixture of pAnti-CD3sFv + pIL-18 in inducing OVA-specific, Th1 immune responses and also in inhibiting OVA-specific, IL-4 production. These studies indicate that vaccination with pAnti-CD3sFv/IL-18 fusion DNA efficiently induces the Th1 immune response in antigen-sensitized mice. | lld:pubmed |
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| pubmed-article:14678196 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14678196 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14678196 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14678196 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14678196 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14678196 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14678196 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:14678196 | pubmed:author | pubmed-author:ChoDD | lld:pubmed |
| pubmed-article:14678196 | pubmed:author | pubmed-author:CHUK MKM | lld:pubmed |
| pubmed-article:14678196 | pubmed:author | pubmed-author:KimE JEJ | lld:pubmed |
| pubmed-article:14678196 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14678196 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:14678196 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14678196 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14678196 | pubmed:pagination | 27-34 | lld:pubmed |
| pubmed-article:14678196 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14678196 | pubmed:meshHeading | pubmed-meshheading:14678196... | lld:pubmed |
| pubmed-article:14678196 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14678196 | pubmed:articleTitle | Efficient induction of T helper type 1-mediated immune responses in antigen-primed mice by anti-CD3 single-chain Fv/interleukin-18 fusion DNA. | lld:pubmed |
| pubmed-article:14678196 | pubmed:affiliation | Immunology Laboratory, College of Pharmacy, Chonnam National University, Kwangju, Korea. | lld:pubmed |
| pubmed-article:14678196 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14678196 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
