| pubmed-article:14654841 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C0010222 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C0528008 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C1423774 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C1880352 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C1707798 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C0184967 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C1705944 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C1522408 | lld:lifeskim |
| pubmed-article:14654841 | lifeskim:mentions | umls-concept:C0453946 | lld:lifeskim |
| pubmed-article:14654841 | pubmed:issue | 6966 | lld:pubmed |
| pubmed-article:14654841 | pubmed:dateCreated | 2003-12-5 | lld:pubmed |
| pubmed-article:14654841 | pubmed:abstractText | Protein coats deform flat lipid membranes into buds and capture membrane proteins to form transport vesicles. The assembly/disassembly cycle of the COPI coat on Golgi membranes is coupled to the GTP/GDP cycle of the small G protein Arf1. At the heart of this coupling is the specific interaction of membrane-bound Arf1-GTP with coatomer, a complex of seven proteins that forms the building unit of the COPI coat. Although COPI coat disassembly requires the catalysis of GTP hydrolysis in Arf1 by a specific GTPase-activating protein (ArfGAP1), the precise timing of this reaction during COPI vesicle formation is not known. Using time-resolved assays for COPI dynamics on liposomes of controlled size, we show that the rate of ArfGAP1-catalysed GTP hydrolysis in Arf1 and the rate of COPI disassembly increase over two orders of magnitude as the curvature of the lipid bilayer increases and approaches that of a typical transport vesicle. This leads to a model for COPI dynamics in which GTP hydrolysis in Arf1 is organized temporally and spatially according to the changes in lipid packing induced by the coat. | lld:pubmed |
| pubmed-article:14654841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14654841 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14654841 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14654841 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14654841 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14654841 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:14654841 | pubmed:author | pubmed-author:GounonPierreP | lld:pubmed |
| pubmed-article:14654841 | pubmed:author | pubmed-author:AntonnyBrunoB | lld:pubmed |
| pubmed-article:14654841 | pubmed:author | pubmed-author:BigayJoëlleJ | lld:pubmed |
| pubmed-article:14654841 | pubmed:author | pubmed-author:RobineauSylvi... | lld:pubmed |
| pubmed-article:14654841 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14654841 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:14654841 | pubmed:volume | 426 | lld:pubmed |
| pubmed-article:14654841 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14654841 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14654841 | pubmed:pagination | 563-6 | lld:pubmed |
| pubmed-article:14654841 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14654841 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14654841 | pubmed:articleTitle | Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. | lld:pubmed |
| pubmed-article:14654841 | pubmed:affiliation | Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, 660 route des Lucioles, 06560 Valbonne-Sophia-Antipolis, France. | lld:pubmed |
| pubmed-article:14654841 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14654841 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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