| pubmed-article:14651599 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C1184808 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C0442025 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C1512901 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C0021516 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C0205125 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:14651599 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:14651599 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14651599 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14651599 | pubmed:abstractText | Interstitial cells in the deep muscular plexus (ICC-DMP) are thought to be essential for neurotransmission in the circular muscle. There is evidence for gap junctions within the ICC-DMP network and between ICC-DMP and muscle cells; however, there is no evidence for functional coupling via these gap junctions. In addition, the innervation of individual ICC-DMP has not been studied. We investigated these questions by injecting the dye Lucifer yellow into ICC-DMP of guinea-pig ileum. Nerves were labelled immunohistochemically for protein gene product 9.5. Cells were imaged by confocal microscopy. Most (79%) of the dye-injected ICC-DMP were coupled to one to five other ICC-DMP, and 86% of them were coupled to one to five circular muscle cells. Octanol effectively blocked all coupling. Incubation in pH 6.8-7.0 reduced ICC-ICC coupling to 49% and ICC-muscle coupling to 32%. In contrast, pH 7.8-7.9 increased ICC-ICC and ICC-muscle coupling to 100%. Most ICC somata (95%) and processes (60%) were in close proximity with both nerve fibres and smooth muscle cells. These results provide direct evidence for functional coupling within the ICC-DMP network, and between this network and cells of the outer circular muscle layer and showed that coupling can be affected by pH. | lld:pubmed |
| pubmed-article:14651599 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14651599 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14651599 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14651599 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14651599 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14651599 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14651599 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14651599 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14651599 | pubmed:issn | 1350-1925 | lld:pubmed |
| pubmed-article:14651599 | pubmed:author | pubmed-author:SzurszewskiJ... | lld:pubmed |
| pubmed-article:14651599 | pubmed:author | pubmed-author:HananiMM | lld:pubmed |
| pubmed-article:14651599 | pubmed:author | pubmed-author:FarrugiaGG | lld:pubmed |
| pubmed-article:14651599 | pubmed:author | pubmed-author:KobiloTT | lld:pubmed |
| pubmed-article:14651599 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14651599 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:14651599 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14651599 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14651599 | pubmed:pagination | 635-41 | lld:pubmed |
| pubmed-article:14651599 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:meshHeading | pubmed-meshheading:14651599... | lld:pubmed |
| pubmed-article:14651599 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14651599 | pubmed:articleTitle | Coupling and innervation patterns of interstitial cells of Cajal in the deep muscular plexus of the guinea-pig. | lld:pubmed |
| pubmed-article:14651599 | pubmed:affiliation | Laboratory of Experimental Surgery, Hadassah University Hospital Mount Scopus and Hebrew University Hadassah Medical School, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:14651599 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14651599 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14651599 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14651599 | lld:pubmed |
