| pubmed-article:14644757 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C1285092 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C1522496 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:14644757 | lifeskim:mentions | umls-concept:C1440080 | lld:lifeskim |
| pubmed-article:14644757 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14644757 | pubmed:dateCreated | 2004-3-8 | lld:pubmed |
| pubmed-article:14644757 | pubmed:abstractText | We tested the hypothesis that interleukin (IL)-1beta-induced cortisol synthesis stimulates alveolar fluid clearance in preterm fetuses. IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. Fetuses were obtained by abdominal hysterotomy at 61 and 68 days gestation and instilled with isosmolar 5% albumin in the lungs, and alveolar fluid movement was measured over 1 h from the change in alveolar protein concentration. Alveolar fluid clearance was induced at 61 days gestation and stimulated at 68 days gestation by IL-1beta, which both were attenuated by cortisol synthesis inhibition. Plasma ACTH and cortisol concentrations were increased by IL-1beta at both gestational ages, and metyrapone reduced cortisol concentrations. IL-1beta was mostly low or undetectable in both fetal and maternal blood. Prenatal alveolar fluid clearance, when present as well as IL-1beta induced, was always propranolol and amiloride sensitive, suggesting that beta-adrenoceptor stimulation and amiloride-sensitive Na+ channels were critical for fluid absorption. IL-1beta increased lung beta-adrenoceptor density at gestation day 61, and cortisol synthesis inhibition attenuated the increased beta-adrenoceptor density. Epithelial Na+ channel and Na+-K+-ATPase subunit expressions were both increased by IL-1beta and attenuated by cortisol synthesis inhibition. These results may explain why babies delivered preterm after intrauterine inflammation have a reduced risk of developing severe respiratory distress. | lld:pubmed |
| pubmed-article:14644757 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14644757 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14644757 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14644757 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:14644757 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:14644757 | pubmed:author | pubmed-author:YowPP | lld:pubmed |
| pubmed-article:14644757 | pubmed:author | pubmed-author:FolkessonHans... | lld:pubmed |
| pubmed-article:14644757 | pubmed:author | pubmed-author:AcharyaReshma... | lld:pubmed |
| pubmed-article:14644757 | pubmed:author | pubmed-author:HerbertJonath... | lld:pubmed |
| pubmed-article:14644757 | pubmed:author | pubmed-author:HamiltonSarah... | lld:pubmed |
| pubmed-article:14644757 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14644757 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:14644757 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14644757 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14644757 | pubmed:pagination | L756-66 | lld:pubmed |
| pubmed-article:14644757 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:14644757 | pubmed:meshHeading | pubmed-meshheading:14644757... | lld:pubmed |
| pubmed-article:14644757 | pubmed:meshHeading | pubmed-meshheading:14644757... | lld:pubmed |
| pubmed-article:14644757 | pubmed:meshHeading | pubmed-meshheading:14644757... | lld:pubmed |
| pubmed-article:14644757 | pubmed:meshHeading | pubmed-meshheading:14644757... | lld:pubmed |
| pubmed-article:14644757 | pubmed:meshHeading | pubmed-meshheading:14644757... | lld:pubmed |
| pubmed-article:14644757 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14644757 | pubmed:articleTitle | IL-1beta stimulates alveolar fluid absorption in fetal guinea pig lungs via the hypothalamus-pituitary-adrenal gland axis. | lld:pubmed |
| pubmed-article:14644757 | pubmed:affiliation | Dept. of Physiology and Pharmacology, Northeastern Ohio Universities, College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272-0095, USA. | lld:pubmed |
| pubmed-article:14644757 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14644757 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14644757 | lld:pubmed |
