| pubmed-article:14642279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0011305 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0031516 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C1421169 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C1160185 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:14642279 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:14642279 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14642279 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14642279 | pubmed:abstractText | Vomeronasal sensory neurons play a crucial role in detecting pheromones, but the chemoelectrical transduction mechanism remains unclear and controversial. A major barrier to the resolution of this question has been the lack of an activation mechanism of a key transduction component, the TRPC2 channel. We have identified a Ca(2+)-permeable cation channel in vomeronasal neuron dendrites that is gated by the lipid messenger diacylglycerol (DAG), independently of Ca(2+) or protein kinase C. We demonstrate that ablation of the TRPC2 gene causes a severe deficit in the DAG-gated channel, indicating that TRPC2 encodes a principal subunit of this channel and that the primary electrical response to pheromones depends on DAG but not Ins(1,4,5)P(3), Ca(2+) stores, or arachidonic acid. Thus, a previously unanticipated mechanism involving direct channel opening by DAG underlies the transduction of sensory cues in the accessory olfactory system. | lld:pubmed |
| pubmed-article:14642279 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14642279 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14642279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14642279 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14642279 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:14642279 | pubmed:author | pubmed-author:Leinders-Zufa... | lld:pubmed |
| pubmed-article:14642279 | pubmed:author | pubmed-author:ZufallFrankF | lld:pubmed |
| pubmed-article:14642279 | pubmed:author | pubmed-author:LucasPhilippe... | lld:pubmed |
| pubmed-article:14642279 | pubmed:author | pubmed-author:UkhanovKyrill... | lld:pubmed |
| pubmed-article:14642279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14642279 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:14642279 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:14642279 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14642279 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14642279 | pubmed:pagination | 551-61 | lld:pubmed |
| pubmed-article:14642279 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14642279 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14642279 | pubmed:articleTitle | A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. | lld:pubmed |
| pubmed-article:14642279 | pubmed:affiliation | Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. | lld:pubmed |
| pubmed-article:14642279 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14642279 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14642279 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:14642279 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14642279 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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