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pubmed-article:14627915pubmed:abstractTextImmature dendritic cells (DCs) have the tolerogenic potential to induce alloantigen-specific immune tolerance. Cytotoxic T lymphocyte antigen 4 immunoglobulin (CTLA4Ig) gene-modified immature DCs have been shown to maintain their tolerogenicity and prolong allograft survival to some extent. We investigated whether blockade of CD40 pathway by anti-CD40 ligand (L) monoclonal antibody (mAb) could enhance the immune tolerance induction by immature DCs genetically modified to express CTLA4Ig (DC-CTLA4Ig).lld:pubmed
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pubmed-article:14627915pubmed:articleTitleBlockade of CD40 pathway enhances the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 immunoglobulin.lld:pubmed
pubmed-article:14627915pubmed:affiliationInstitute of Immunology, Zhejiang University, Hangzhou, China.lld:pubmed
pubmed-article:14627915pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14627915pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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