| pubmed-article:14627307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C0018795 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C0002771 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C0022614 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:14627307 | lifeskim:mentions | umls-concept:C0036557 | lld:lifeskim |
| pubmed-article:14627307 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14627307 | pubmed:dateCreated | 2003-11-20 | lld:pubmed |
| pubmed-article:14627307 | pubmed:abstractText | The hypnotic and analgesic effect of ketamine with maintained spontaneous breathing is used for analgesic/sedative anesthesia without the need of intubation. The intention of this study was to compare the efficacy and side effects of racemic ketamine and its enantiomer S(+)-ketamine during cardiac catheterization in newborns and children. One hundred children (ages 0-11 years) were randomly assigned to groups of equal size. The differences between the racemic ketamine/midazolam and the S(+)-ketamine/midazolam groups were investigated regarding the total dosage of sedative drugs, side effects, and the awakening period. The dosage of S(+)-ketamine (2.28 mg/kg/h) was significantly lower than that needed for racemic ketamine (3.12 mg/kg/h) (p = 0.037) with an analgesic/sedative potency ratio of 1.4:1. Balloon dilatation required significantly higher dosages in both groups (p = 0.043). Significantly more patients were excluded because of ineffective analgesia/sedation or severe side effects in the racemic ketamine group. The awakening period did not show significant differences between the two groups. S(+)-ketamine proved to be a more efficient analgesic/sedative drug in newborns and children. It was shown to be useful in diagnostic and interventional procedures and allows spontaneous breathing. Moderate side effects occurred in both groups; severe side effects seemed to occur more often with the racemic solution. | lld:pubmed |
| pubmed-article:14627307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14627307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14627307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14627307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14627307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14627307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14627307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14627307 | pubmed:issn | 0172-0643 | lld:pubmed |
| pubmed-article:14627307 | pubmed:author | pubmed-author:BergerFF | lld:pubmed |
| pubmed-article:14627307 | pubmed:author | pubmed-author:PeerBB | lld:pubmed |
| pubmed-article:14627307 | pubmed:author | pubmed-author:LangeP EPE | lld:pubmed |
| pubmed-article:14627307 | pubmed:author | pubmed-author:EwertPP | lld:pubmed |
| pubmed-article:14627307 | pubmed:author | pubmed-author:HaasN ANA | lld:pubmed |
| pubmed-article:14627307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14627307 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:14627307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14627307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14627307 | pubmed:pagination | 424-9 | lld:pubmed |
| pubmed-article:14627307 | pubmed:dateRevised | 2008-2-20 | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:meshHeading | pubmed-meshheading:14627307... | lld:pubmed |
| pubmed-article:14627307 | pubmed:articleTitle | Comparison of analgesic/sedative effect of racemic ketamine and S(+)-ketamine during cardiac catheterization in newborns and children. | lld:pubmed |
| pubmed-article:14627307 | pubmed:affiliation | German Heart Institute, Department of Congenital Heart Defects/Pediatrics Cardiology, Augustenburger Platz 1, D-13353 Berlin, Germany. | lld:pubmed |
| pubmed-article:14627307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14627307 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:14627307 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14627307 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:14627307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14627307 | lld:pubmed |
