| pubmed-article:14614165 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14614165 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:14614165 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:14614165 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:14614165 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:14614165 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:14614165 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:14614165 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:14614165 | pubmed:dateCreated | 2003-11-17 | lld:pubmed |
| pubmed-article:14614165 | pubmed:abstractText | Effective new therapies are needed for rheumatoid arthritis. Current therapies target the products of activated macrophages; however, T cells also have an important role in rheumatoid arthritis. A fusion protein--cytotoxic T-lymphocyte-associated antigen 4-IgG1 (CTLA4Ig)--is the first in a new class of drugs known as costimulation blockers being evaluated for the treatment of rheumatoid arthritis. CTLA4Ig binds to CD80 and CD86 on antigen-presenting cells, blocking the engagement of CD28 on T cells and preventing T-cell activation. A preliminary study showed that CTLA4Ig may be effective for the treatment of rheumatoid arthritis. | lld:pubmed |
| pubmed-article:14614165 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14614165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14614165 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:14614165 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14614165 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14614165 | pubmed:issn | 1533-4406 | lld:pubmed |
| pubmed-article:14614165 | pubmed:author | pubmed-author:EmeryPaulP | lld:pubmed |
| pubmed-article:14614165 | pubmed:author | pubmed-author:DougadosMaxim... | lld:pubmed |
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| pubmed-article:14614165 | pubmed:author | pubmed-author:AltenRiekeR | lld:pubmed |
| pubmed-article:14614165 | pubmed:author | pubmed-author:LeonMarcM | lld:pubmed |
| pubmed-article:14614165 | pubmed:author | pubmed-author:BeckerJean-Cl... | lld:pubmed |
| pubmed-article:14614165 | pubmed:author | pubmed-author:KremerJoel... | lld:pubmed |
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| pubmed-article:14614165 | pubmed:author | pubmed-author:HagertyDavid... | lld:pubmed |
| pubmed-article:14614165 | pubmed:copyrightInfo | Copyright 2003 Massachusetts Medical Society | lld:pubmed |
| pubmed-article:14614165 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:14614165 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:14614165 | pubmed:volume | 349 | lld:pubmed |
| pubmed-article:14614165 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14614165 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14614165 | pubmed:pagination | 1907-15 | lld:pubmed |
| pubmed-article:14614165 | pubmed:dateRevised | 2006-5-17 | lld:pubmed |
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| pubmed-article:14614165 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14614165 | pubmed:articleTitle | Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. | lld:pubmed |
| pubmed-article:14614165 | pubmed:affiliation | Center for Rheumatology, Albany, NY 12206, USA. jkremer@joint-docs.com | lld:pubmed |
| pubmed-article:14614165 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14614165 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:14614165 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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