| pubmed-article:1461282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1461282 | lifeskim:mentions | umls-concept:C0206535 | lld:lifeskim |
| pubmed-article:1461282 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:1461282 | lifeskim:mentions | umls-concept:C0115220 | lld:lifeskim |
| pubmed-article:1461282 | lifeskim:mentions | umls-concept:C1449958 | lld:lifeskim |
| pubmed-article:1461282 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:1461282 | pubmed:issue | 6404 | lld:pubmed |
| pubmed-article:1461282 | pubmed:dateCreated | 1993-1-12 | lld:pubmed |
| pubmed-article:1461282 | pubmed:abstractText | Dystrophin is associated with a complex of muscle membrane (sarcolemmal) glycoproteins that provide a linkage to the extracellular matrix protein, laminin. The absence of dystrophin leads to a dramatic reduction of the dystrophin-associated proteins (156DAG, 59DAP, 50DAG, 43DAG and 35DAG) in the sarcolemma of patients with Duchenne muscular dystrophy and mdx mice. Here we demonstrate that dystrophin-related protein (DRP, utrophin), an autosomal homologue of dystrophin, is associated with an identical or antigenically similar complex of sarcolemmal proteins and that DRP and the dystrophin/DRP-associated proteins colocalize to the neuromuscular junction in Duchenne muscular dystrophy and mdx muscle. The DRP and dystrophin/DRP-associated proteins are found throughout the sarcolemma in small-calibre skeletal muscles and cardiac muscle of adult mdx mice. Because these muscles show minimal pathological changes, our results could provide a basis for the upregulation of DRP as a potential therapeutic approach. | lld:pubmed |
| pubmed-article:1461282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1461282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1461282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1461282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1461282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1461282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1461282 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1461282 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1461282 | pubmed:author | pubmed-author:MatsumuraKK | lld:pubmed |
| pubmed-article:1461282 | pubmed:author | pubmed-author:CampbellK PKP | lld:pubmed |
| pubmed-article:1461282 | pubmed:author | pubmed-author:KahlS DSD | lld:pubmed |
| pubmed-article:1461282 | pubmed:author | pubmed-author:OhlendieckKK | lld:pubmed |
| pubmed-article:1461282 | pubmed:author | pubmed-author:ErvastiJ MJM | lld:pubmed |
| pubmed-article:1461282 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1461282 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:1461282 | pubmed:volume | 360 | lld:pubmed |
| pubmed-article:1461282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1461282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1461282 | pubmed:pagination | 588-91 | lld:pubmed |
| pubmed-article:1461282 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1461282 | pubmed:meshHeading | pubmed-meshheading:1461282-... | lld:pubmed |
| pubmed-article:1461282 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1461282 | pubmed:articleTitle | Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle. | lld:pubmed |
| pubmed-article:1461282 | pubmed:affiliation | Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242. | lld:pubmed |
| pubmed-article:1461282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1461282 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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