| pubmed-article:14577850 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14577850 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:14577850 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:14577850 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:14577850 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14577850 | lifeskim:mentions | umls-concept:C2698172 | lld:lifeskim |
| pubmed-article:14577850 | lifeskim:mentions | umls-concept:C1708533 | lld:lifeskim |
| pubmed-article:14577850 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14577850 | pubmed:dateCreated | 2003-10-27 | lld:pubmed |
| pubmed-article:14577850 | pubmed:abstractText | The intestinal epithelium provides a critical interface between lumenal bacteria and the mucosal immune system. Whereas normal commensal flora do not trigger acute inflammation, pathogenic bacteria trigger a potent inflammatory response. Our studies emanate from the hypothesis that the intestinal epithelium is normally hyporesponsive to commensal pathogen-associated molecular patterns (PAMPs) such as LPS. Our data demonstrate that normal human colonic epithelial cells and lamina propria cells express low levels of TLR4 and its co-receptor MD-2. This expression pattern is mirrored by intestinal epithelial cell (IEC) lines. Co-expression of TLR4 and MD-2 is necessary and sufficient for LPS responsiveness in IEC. Moreover, LPS sensing occurs along the basolateral membrane of polarized IEC in culture. Expression of MD-2 is regulated by IFN-gamma. Cloning of the MD-2 promoter demonstrates that promoter activity is increased by IFN-gamma and blocked by the STAT inhibitor SOCS3. We conclude from our studies that the intestinal epithelium down-regulates expression of TLR4 and MD-2 and is LPS unresponsive. The Th1 cytokine IFN-gamma up-regulates expression of MD-2 in a STAT-dependent fashion. The results of our studies have important implications for understanding human inflammatory bowel diseases. | lld:pubmed |
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| pubmed-article:14577850 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14577850 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14577850 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14577850 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14577850 | pubmed:issn | 0968-0519 | lld:pubmed |
| pubmed-article:14577850 | pubmed:author | pubmed-author:MichelsenKath... | lld:pubmed |
| pubmed-article:14577850 | pubmed:author | pubmed-author:ArditiMosheM | lld:pubmed |
| pubmed-article:14577850 | pubmed:author | pubmed-author:AbreuMaria... | lld:pubmed |
| pubmed-article:14577850 | pubmed:author | pubmed-author:ArnoldElizabe... | lld:pubmed |
| pubmed-article:14577850 | pubmed:author | pubmed-author:ThomasLisa... | lld:pubmed |
| pubmed-article:14577850 | pubmed:author | pubmed-author:LukasekKatieK | lld:pubmed |
| pubmed-article:14577850 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14577850 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:14577850 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14577850 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14577850 | pubmed:pagination | 322-30 | lld:pubmed |
| pubmed-article:14577850 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:14577850 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14577850 | pubmed:articleTitle | TLR signaling at the intestinal epithelial interface. | lld:pubmed |
| pubmed-article:14577850 | pubmed:affiliation | Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. maria.abreu@cshs.org | lld:pubmed |
| pubmed-article:14577850 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14577850 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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