| pubmed-article:14561773 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14561773 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:14561773 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:14561773 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:14561773 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:14561773 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:14561773 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:14561773 | pubmed:dateCreated | 2003-10-16 | lld:pubmed |
| pubmed-article:14561773 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14561773 | pubmed:abstractText | The Brain Tumor (Brat) protein is recruited to the 3' untranslated region (UTR) of hunchback mRNA to regulate its translation. Recruitment is mediated by interactions between the Pumilio RNA-binding Puf repeats and the NHL domain of Brat, a conserved structural motif present in a large family of growth regulators. In this report, we describe the crystal structure of the Brat NHL domain and present a model of the Pumilio-Brat complex derived from in silico docking experiments and supported by mutational analysis of the protein-protein interface. A key feature of the model is recognition of the outer, convex surface of the Pumilio Puf domain by the top, electropositive face of the six-bladed Brat beta-propeller. In particular, an extended loop in Puf repeat 8 fits in the entrance to the central channel of the Brat beta-propeller. Together, these interactions are likely to be prototypic of the recruitment strategies of other NHL-containing proteins in development. | lld:pubmed |
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| pubmed-article:14561773 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14561773 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14561773 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14561773 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14561773 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14561773 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:14561773 | pubmed:author | pubmed-author:EdwardsThomas... | lld:pubmed |
| pubmed-article:14561773 | pubmed:author | pubmed-author:AggarwalAneel... | lld:pubmed |
| pubmed-article:14561773 | pubmed:author | pubmed-author:WhartonRobin... | lld:pubmed |
| pubmed-article:14561773 | pubmed:author | pubmed-author:WilkinsonBria... | lld:pubmed |
| pubmed-article:14561773 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14561773 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14561773 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:14561773 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14561773 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14561773 | pubmed:pagination | 2508-13 | lld:pubmed |
| pubmed-article:14561773 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14561773 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14561773 | pubmed:articleTitle | Model of the brain tumor-Pumilio translation repressor complex. | lld:pubmed |
| pubmed-article:14561773 | pubmed:affiliation | Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA. | lld:pubmed |
| pubmed-article:14561773 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14561773 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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