| pubmed-article:14561772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0029974 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0037868 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0079474 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0036488 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:14561772 | lifeskim:mentions | umls-concept:C1328825 | lld:lifeskim |
| pubmed-article:14561772 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:14561772 | pubmed:dateCreated | 2003-10-16 | lld:pubmed |
| pubmed-article:14561772 | pubmed:abstractText | Species-specific adhesion of sperm to the egg during sea urchin fertilization involves the interaction of the sperm adhesive protein,bindin, and a complementary receptor on the egg surface,and serves to restrict the gene pool to individuals of the same species. We used PCR representation difference analysis to clone the species-specific egg receptor for bindin, EBR1, from Strongylocentrotus franciscanus (Sf) and S. purpuratus (Sp). Sf-EBR1 contains a novel ADAMTS-like N-terminal domain followed by approximately 19 tandem EBR repeats consisting of alternating CUB and thrombospondin type 1 (TSP-1) domains where the last 10 EBR repeats are species-specific and highly conserved. Recombinant protein corresponding to the species-specific EBR repeat displays species-specific sperm adhesion and bindin-binding activity. The Sp-EBR1 ortholog has the same ADAMTS (a disintegrin and metalloprotease with thrombospondin type-1 modules) core region followed by eight and one-half tandem egg bindin receptor (EBR) repeats that share 88% identity with the Sf-EBR1 repeats,but has an entirely different species-specific domain consisting of hyalin-like (HYR) repeats. Thus,the species-specific domains of egg bindin receptor 1 (EBR1) from both species function as the egg surface receptor to mediate species-specific sperm adhesion. | lld:pubmed |
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| pubmed-article:14561772 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14561772 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14561772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14561772 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14561772 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:14561772 | pubmed:author | pubmed-author:GlabeCharles... | lld:pubmed |
| pubmed-article:14561772 | pubmed:author | pubmed-author:KameiNorikoN | lld:pubmed |
| pubmed-article:14561772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14561772 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14561772 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:14561772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14561772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14561772 | pubmed:pagination | 2502-7 | lld:pubmed |
| pubmed-article:14561772 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:14561772 | pubmed:meshHeading | pubmed-meshheading:14561772... | lld:pubmed |
| pubmed-article:14561772 | pubmed:meshHeading | pubmed-meshheading:14561772... | lld:pubmed |
| pubmed-article:14561772 | pubmed:meshHeading | pubmed-meshheading:14561772... | lld:pubmed |
| pubmed-article:14561772 | pubmed:meshHeading | pubmed-meshheading:14561772... | lld:pubmed |
| pubmed-article:14561772 | pubmed:meshHeading | pubmed-meshheading:14561772... | lld:pubmed |
| pubmed-article:14561772 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14561772 | pubmed:articleTitle | The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS protein. | lld:pubmed |
| pubmed-article:14561772 | pubmed:affiliation | Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, USA. nkamei@uci.edu | lld:pubmed |
| pubmed-article:14561772 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:577775 | entrezgene:pubmed | pubmed-article:14561772 | lld:entrezgene |
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