| pubmed-article:14560041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C0031307 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C0005767 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C0066411 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C1513475 | lld:lifeskim |
| pubmed-article:14560041 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:14560041 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14560041 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14560041 | pubmed:abstractText | Opioid abuse has been postulated as a cofactor in the immunopathogenesis of human immunodeficiency virus (HIV) infection and AIDS. We and others have recently demonstrated that opioid enhances HIV infection of human macrophages through modulation of beta-chemokines and the CCR5 receptor and that this effect is reversed by naltrexone, a tertiary opioid antagonist. Tertiary opioid antagonists cannot be used in opioid-dependent patients because they precipitate withdrawal or reversal of analgesia. We determined whether the quaternary opioid antagonist methylnaltrexone (MNTX), now in phase III clinical trials for opioid-induced constipation, reverses the opioid-mediated enhancement of HIV infection of macrophages at clinically relevant doses. MNTX completely abrogated morphine-induced HIV Bal strain infection of macrophages. MNTX also inhibited the R5 strain (ADA) envelope-pseudotyped HIV replication induced by morphine. Furthermore, MNTX abolished morphine-mediated up-regulation of CCR5 receptor expression. The ability of MNTX to block opioid-induced CCR5 expression and HIV replication at clinically relevant doses may have additional benefit for opioid abusers with HIV infection, or patients with AIDS pain receiving opioids. | lld:pubmed |
| pubmed-article:14560041 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14560041 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14560041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14560041 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14560041 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:14560041 | pubmed:author | pubmed-author:YuanChun-SuCS | lld:pubmed |
| pubmed-article:14560041 | pubmed:author | pubmed-author:GuoChang-Jian... | lld:pubmed |
| pubmed-article:14560041 | pubmed:author | pubmed-author:DouglasSteven... | lld:pubmed |
| pubmed-article:14560041 | pubmed:author | pubmed-author:HoWen-ZheWZ | lld:pubmed |
| pubmed-article:14560041 | pubmed:author | pubmed-author:MossJonathanJ | lld:pubmed |
| pubmed-article:14560041 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14560041 | pubmed:volume | 307 | lld:pubmed |
| pubmed-article:14560041 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14560041 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14560041 | pubmed:pagination | 1158-62 | lld:pubmed |
| pubmed-article:14560041 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:meshHeading | pubmed-meshheading:14560041... | lld:pubmed |
| pubmed-article:14560041 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14560041 | pubmed:articleTitle | Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes. | lld:pubmed |
| pubmed-article:14560041 | pubmed:affiliation | Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. | lld:pubmed |
| pubmed-article:14560041 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14560041 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14560041 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14560041 | lld:pubmed |
