| pubmed-article:14556998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0596972 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C1510483 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0524909 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0449851 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C1521743 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0181904 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C1704646 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C0728873 | lld:lifeskim |
| pubmed-article:14556998 | lifeskim:mentions | umls-concept:C1512948 | lld:lifeskim |
| pubmed-article:14556998 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14556998 | pubmed:dateCreated | 2003-10-14 | lld:pubmed |
| pubmed-article:14556998 | pubmed:abstractText | Frequent analysis of the intrahepatic cellular immune response during chronic hepatitis B infection is not feasible with the liver tissue biopsy technique, due to its risk profile and patient discomfort. We investigated whether the relatively safe and patient-friendly cytological fine-needle aspiration biopsy (FNAB) technique is suited for this purpose. FNABs taken during hepatitis flares in three chronic hepatitis B patients treated with interferon-alpha, showed significant increments of CD8(+)-lymphocytes compared with the FNABs taken before and after the flares. No increments were observed in peripheral blood. The increments of intrahepatic CD8+ lymphocytes detected by the FNAB were related to anti-viral immune reactivity, since they coincided with significant serum hepatitis B virus DNA level reductions and in two of three patients with HBeAg seroconversion. In conclusion, the FNAB technique is suited to investigate the intrahepatic immune response during chronic hepatitis B infection on a frequent basis. | lld:pubmed |
| pubmed-article:14556998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14556998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14556998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14556998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14556998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14556998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14556998 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14556998 | pubmed:issn | 0928-8244 | lld:pubmed |
| pubmed-article:14556998 | pubmed:author | pubmed-author:KustersJohann... | lld:pubmed |
| pubmed-article:14556998 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:14556998 | pubmed:author | pubmed-author:SchalmSolko... | lld:pubmed |
| pubmed-article:14556998 | pubmed:author | pubmed-author:KwekkeboomJaa... | lld:pubmed |
| pubmed-article:14556998 | pubmed:author | pubmed-author:JanssenHarry... | lld:pubmed |
| pubmed-article:14556998 | pubmed:author | pubmed-author:TangThjon JTJ | lld:pubmed |
| pubmed-article:14556998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14556998 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:14556998 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:14556998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14556998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14556998 | pubmed:pagination | 69-72 | lld:pubmed |
| pubmed-article:14556998 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:meshHeading | pubmed-meshheading:14556998... | lld:pubmed |
| pubmed-article:14556998 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14556998 | pubmed:articleTitle | The intrahepatic immune response during chronic hepatitis B infection can be monitored by the fine-needle aspiration biopsy technique. | lld:pubmed |
| pubmed-article:14556998 | pubmed:affiliation | Department of Gastroenterology and Hepatology, Room L-455, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. | lld:pubmed |
| pubmed-article:14556998 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14556998 | lld:pubmed |
