| pubmed-article:14551207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C0667830 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C1333573 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C1333633 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C0118111 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C1413357 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:14551207 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:14551207 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14551207 | pubmed:dateCreated | 2004-1-5 | lld:pubmed |
| pubmed-article:14551207 | pubmed:abstractText | FLICE-inhibitory protein (FLIP) is a homolog of caspase-8 that lacks catalytic activity and has been shown to be important in protecting endothelial cells from apoptosis. The serine/threonine kinase Akt/PKB was recently reported to promote FLIP expression in endothelial and tumor cells. Here we examined the role of the forkhead transcription factor FOXO3a, a downstream target of Akt, in controlling FLIP regulation in endothelial cells. FOXO3a nuclear translocation was regulated by Akt in human umbilical vein endothelial cells. Transduction of a nonphosphorylatable, constitutively active mutant of FOXO3a (TM-FOXO3a) led to the down-regulation of FLIP levels. Transduction with TM-FOXO3a also increased caspase-8 activity and promoted apoptosis in endothelial cells. Conversely, transduction of a dominant-negative mutant of FOXO3a up-regulated FLIP levels and protected endothelial cells from apoptosis under serum deprivation conditions. Restoration of intracellular FLIP blocked caspase-8 activation and inhibited apoptosis in TM-FOXO3a-transduced cells. These data suggest that FOXO3a is a downstream target of Akt in endothelial cells that can promote apoptosis via FLIP down-regulation and activation of the extrinsic apoptotic pathway. | lld:pubmed |
| pubmed-article:14551207 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14551207 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14551207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14551207 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14551207 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:WalshKennethK | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:KimHyo-SooHS | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:JiangYangY | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:AirdWilliam... | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:SkurkCarstenC | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:AbidMd... | lld:pubmed |
| pubmed-article:14551207 | pubmed:author | pubmed-author:MaatzHenrikeH | lld:pubmed |
| pubmed-article:14551207 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14551207 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:14551207 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:14551207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14551207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14551207 | pubmed:pagination | 1513-25 | lld:pubmed |
| pubmed-article:14551207 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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