Linked Life Data

14529564

Source:http://linkedlifedata.com/resource/pubmed/id/14529564

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14529564rdf:typepubmed:Citationlld:pubmed
pubmed-article:14529564lifeskim:mentionsumls-concept:C1512505lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C0034804lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C0288472lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C1512474lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C0441655lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C0442805lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C0249197lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C1420626lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C2003941lld:lifeskim
pubmed-article:14529564lifeskim:mentionsumls-concept:C2266853lld:lifeskim
pubmed-article:14529564pubmed:issue1lld:pubmed
pubmed-article:14529564pubmed:dateCreated2003-10-7lld:pubmed
pubmed-article:14529564pubmed:abstractTextWe analysed the antiproliferative activity of various histone deacetylase (HDAC) inhibitors such as trichostatin A (TSA) on human breast cancer cells. We observed a lower sensitivity to HDAC inhibition for oestrogen receptor negative (ER-) versus positive (ER+) cell lines. This differential response was associated neither with a modification of drug efflux via the multidrug resistance system nor with a global modification of histone acetyltransferase (HAT)/HDAC activities. In contrast, we demonstrated that in ER+ breast cancer cells the p21(WAF1/CIP1) gene was more sensitive to TSA regulation and was expressed at higher levels. These differences were observed both in transient transfection experiments and on the endogenous p21(WAF1/CIP1) gene. The Sp1 transcription factor, which was shown to interact in vitro with both class I and class II HDACs, is sufficient to confer the differential sensitivity to TSA and participated in the control of p21(WAF1/CIP1) basal expression. Finally, re-expression of ERalpha following adenoviral infection of ER- breast cancer cells increased both p21(WAF1/CIP1) protein accumulation and the growth inhibitory activity of TSA. Altogether, our results highlight the key role of ERalpha and p21(WAF1/CIP1) gene expression in the sensitivity of breast cancer cells to hyperacetylating agents.lld:pubmed
pubmed-article:14529564pubmed:languageenglld:pubmed
pubmed-article:14529564pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:citationSubsetIMlld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14529564pubmed:statusMEDLINElld:pubmed
pubmed-article:14529564pubmed:monthOctlld:pubmed
pubmed-article:14529564pubmed:issn0022-0795lld:pubmed
pubmed-article:14529564pubmed:authorpubmed-author:VignonFFlld:pubmed
pubmed-article:14529564pubmed:authorpubmed-author:CavaillèsVVlld:pubmed
pubmed-article:14529564pubmed:authorpubmed-author:LazennecGGlld:pubmed
pubmed-article:14529564pubmed:authorpubmed-author:MargueronRRlld:pubmed
pubmed-article:14529564pubmed:authorpubmed-author:LicznarAAlld:pubmed
pubmed-article:14529564pubmed:issnTypePrintlld:pubmed
pubmed-article:14529564pubmed:volume179lld:pubmed
pubmed-article:14529564pubmed:ownerNLMlld:pubmed
pubmed-article:14529564pubmed:authorsCompleteYlld:pubmed
pubmed-article:14529564pubmed:pagination41-53lld:pubmed
pubmed-article:14529564pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:meshHeadingpubmed-meshheading:14529564...lld:pubmed
pubmed-article:14529564pubmed:year2003lld:pubmed
pubmed-article:14529564pubmed:articleTitleOestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells.lld:pubmed
pubmed-article:14529564pubmed:affiliationINSERM U540, Endocrinologie Moléculaire et Cellulaire des Cancers and Université de Montpellier I, 60, rue de Navacelles, 34090 Montpellier, France.lld:pubmed
pubmed-article:14529564pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14529564pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14529564lld:pubmed