| pubmed-article:14528312 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14528312 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:14528312 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:14528312 | lifeskim:mentions | umls-concept:C1157998 | lld:lifeskim |
| pubmed-article:14528312 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:14528312 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:14528312 | pubmed:dateCreated | 2003-10-31 | lld:pubmed |
| pubmed-article:14528312 | pubmed:abstractText | The concentrations and functions of many cellular proteins are regulated by the ubiquitin pathway. Cullin family proteins bind with the RING-finger protein Roc1 to recruit the ubiquitin-conjugating enzyme (E2) to the ubiquitin ligase complex (E3). Cul1 and Cul7, but not other cullins, bind to an adaptor protein, Skp1. Cul1 associates with one of many F-box proteins through Skp1 to assemble various SCF-Roc1 E3 ligases that each selectively ubiquitinate one or more specific substrates. Here, we show that Cul3, but not other cullins, binds directly to multiple BTB domains through a conserved amino-terminal domain. In vitro, Cul3 promoted ubiquitination of Caenorhabditis elegans MEI-1, a katanin-like protein whose degradation requires the function of both Cul3 and BTB protein MEL-26. We suggest that in vivo there exists a potentially large number of BCR3 (BTB-Cul3-Roc1) E3 ubiquitin ligases. | lld:pubmed |
| pubmed-article:14528312 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14528312 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14528312 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14528312 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14528312 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14528312 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14528312 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14528312 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14528312 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:14528312 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:14528312 | pubmed:author | pubmed-author:XiongYueY | lld:pubmed |
| pubmed-article:14528312 | pubmed:author | pubmed-author:FurukawaManab... | lld:pubmed |
| pubmed-article:14528312 | pubmed:author | pubmed-author:BorchersChris... | lld:pubmed |
| pubmed-article:14528312 | pubmed:author | pubmed-author:HeYizhou... | lld:pubmed |
| pubmed-article:14528312 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14528312 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:14528312 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14528312 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14528312 | pubmed:pagination | 1001-7 | lld:pubmed |
| pubmed-article:14528312 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14528312 | pubmed:meshHeading | pubmed-meshheading:14528312... | lld:pubmed |
| pubmed-article:14528312 | pubmed:meshHeading | pubmed-meshheading:14528312... | lld:pubmed |
| pubmed-article:14528312 | pubmed:meshHeading | pubmed-meshheading:14528312... | lld:pubmed |
| pubmed-article:14528312 | pubmed:meshHeading | pubmed-meshheading:14528312... | lld:pubmed |
| pubmed-article:14528312 | pubmed:meshHeading | pubmed-meshheading:14528312... | lld:pubmed |
| pubmed-article:14528312 | pubmed:meshHeading | pubmed-meshheading:14528312... | lld:pubmed |
| pubmed-article:14528312 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14528312 | pubmed:articleTitle | Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. | lld:pubmed |
| pubmed-article:14528312 | pubmed:affiliation | Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, NC 27599-7295, USA. | lld:pubmed |
| pubmed-article:14528312 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14528312 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14528312 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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